Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Archaerhodopsin-3 (AR3) mutants are commonly used in optogenetics for neuron silencing and membrane voltage sensing. High-resolution crystal structures show that desensitization of the AR3 photoreceptor occurs when internal hydrogen-bonded water networks are modified in response to changes in chromo...

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Autores principales:	Juan F. Bada Juarez, Peter J. Judge, Suliman Adam, Danny Axford, Javier Vinals, James Birch, Tristan O. C. Kwan, Kin Kuan Hoi, Hsin-Yung Yen, Anthony Vial, Pierre-Emmanuel Milhiet, Carol V. Robinson, Igor Schapiro, Isabel Moraes, Anthony Watts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/039fb047d8d74a55a61854b573e871d6
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spelling	oai:doaj.org-article:039fb047d8d74a55a61854b573e871d62021-12-02T13:27:30ZStructures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization10.1038/s41467-020-20596-02041-1723https://doaj.org/article/039fb047d8d74a55a61854b573e871d62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20596-0https://doaj.org/toc/2041-1723Archaerhodopsin-3 (AR3) mutants are commonly used in optogenetics for neuron silencing and membrane voltage sensing. High-resolution crystal structures show that desensitization of the AR3 photoreceptor occurs when internal hydrogen-bonded water networks are modified in response to changes in chromophore isomerization.Juan F. Bada JuarezPeter J. JudgeSuliman AdamDanny AxfordJavier VinalsJames BirchTristan O. C. KwanKin Kuan HoiHsin-Yung YenAnthony VialPierre-Emmanuel MilhietCarol V. RobinsonIgor SchapiroIsabel MoraesAnthony WattsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juan F. Bada Juarez Peter J. Judge Suliman Adam Danny Axford Javier Vinals James Birch Tristan O. C. Kwan Kin Kuan Hoi Hsin-Yung Yen Anthony Vial Pierre-Emmanuel Milhiet Carol V. Robinson Igor Schapiro Isabel Moraes Anthony Watts Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
description	Archaerhodopsin-3 (AR3) mutants are commonly used in optogenetics for neuron silencing and membrane voltage sensing. High-resolution crystal structures show that desensitization of the AR3 photoreceptor occurs when internal hydrogen-bonded water networks are modified in response to changes in chromophore isomerization.
format	article
author	Juan F. Bada Juarez Peter J. Judge Suliman Adam Danny Axford Javier Vinals James Birch Tristan O. C. Kwan Kin Kuan Hoi Hsin-Yung Yen Anthony Vial Pierre-Emmanuel Milhiet Carol V. Robinson Igor Schapiro Isabel Moraes Anthony Watts
author_facet	Juan F. Bada Juarez Peter J. Judge Suliman Adam Danny Axford Javier Vinals James Birch Tristan O. C. Kwan Kin Kuan Hoi Hsin-Yung Yen Anthony Vial Pierre-Emmanuel Milhiet Carol V. Robinson Igor Schapiro Isabel Moraes Anthony Watts
author_sort	Juan F. Bada Juarez
title	Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
title_short	Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
title_full	Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
title_fullStr	Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
title_full_unstemmed	Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
title_sort	structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/039fb047d8d74a55a61854b573e871d6
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Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

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