A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity
5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K i value of 0.445 ± 0.013 µM.
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| Main Authors: | , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
De Gruyter
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/03a0d48773c847ef8df4ffe894c420df |
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| Summary: | 5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K
i value of 0.445 ± 0.013 µM. |
|---|