A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity
5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K i value of 0.445 ± 0.013 µM.
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De Gruyter
2021
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oai:doaj.org-article:03a0d48773c847ef8df4ffe894c420df2021-12-05T14:10:43ZA new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity2391-542010.1515/chem-2021-0032https://doaj.org/article/03a0d48773c847ef8df4ffe894c420df2021-03-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0032https://doaj.org/toc/2391-54205-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K i value of 0.445 ± 0.013 µM.Sever BelginAltıntop Mehlika DilekDemir YelizTürkeş CüneytÖzbaş KaanÇiftçi Gülşen AkalınBeydemir ŞükrüÖzdemir AhmetDe Gruyterarticlealdose reductasethiazolidinedionecytotoxicitymolecular dockingChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 347-357 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
aldose reductase thiazolidinedione cytotoxicity molecular docking Chemistry QD1-999 |
| spellingShingle |
aldose reductase thiazolidinedione cytotoxicity molecular docking Chemistry QD1-999 Sever Belgin Altıntop Mehlika Dilek Demir Yeliz Türkeş Cüneyt Özbaş Kaan Çiftçi Gülşen Akalın Beydemir Şükrü Özdemir Ahmet A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity |
| description |
5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K
i value of 0.445 ± 0.013 µM. |
| format |
article |
| author |
Sever Belgin Altıntop Mehlika Dilek Demir Yeliz Türkeş Cüneyt Özbaş Kaan Çiftçi Gülşen Akalın Beydemir Şükrü Özdemir Ahmet |
| author_facet |
Sever Belgin Altıntop Mehlika Dilek Demir Yeliz Türkeş Cüneyt Özbaş Kaan Çiftçi Gülşen Akalın Beydemir Şükrü Özdemir Ahmet |
| author_sort |
Sever Belgin |
| title |
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity |
| title_short |
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity |
| title_full |
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity |
| title_fullStr |
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity |
| title_full_unstemmed |
A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity |
| title_sort |
new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity |
| publisher |
De Gruyter |
| publishDate |
2021 |
| url |
https://doaj.org/article/03a0d48773c847ef8df4ffe894c420df |
| work_keys_str_mv |
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