A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity

5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K i value of 0.445 ± 0.013 µM.

Guardado en:
Detalles Bibliográficos
Autores principales: Sever Belgin, Altıntop Mehlika Dilek, Demir Yeliz, Türkeş Cüneyt, Özbaş Kaan, Çiftçi Gülşen Akalın, Beydemir Şükrü, Özdemir Ahmet
Formato: article
Lenguaje:EN
Publicado: De Gruyter 2021
Materias:
Acceso en línea:https://doaj.org/article/03a0d48773c847ef8df4ffe894c420df
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares