A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity
5-(2-Hydroxy-3-methylbenzylidene)thiazolidine-2,4-dione (3) was identified as the most potent AR inhibitor in this series, exerting uncompetitive inhibition with a K i value of 0.445 ± 0.013 µM.
Guardado en:
Autores principales: | Sever Belgin, Altıntop Mehlika Dilek, Demir Yeliz, Türkeş Cüneyt, Özbaş Kaan, Çiftçi Gülşen Akalın, Beydemir Şükrü, Özdemir Ahmet |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
De Gruyter
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/03a0d48773c847ef8df4ffe894c420df |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Demethylbellidifolin, a potential aldose reductase inhibitor ameliorates diabetic nephropathy by regulating the polyol pathway
por: Haifei Xie, et al.
Publicado: (2022) -
Corrosion Inhibition Properties of Thiazolidinedione Derivatives for Copper in 3.5 wt.% NaCl Medium
por: Hassane Lgaz, et al.
Publicado: (2021) -
Diabetes autoinmune (latente) del adulto
por: Pollak C,Felipe, et al.
Publicado: (2012) -
Long-term safety and tolerability of saxagliptin add-on therapy in older patients (aged ≥65 years) with type 2 diabetes
por: Iqbal N, et al.
Publicado: (2014) -
Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression
por: Giulia Cantini, et al.
Publicado: (2021)