Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients

Giuseppe Derosa,1–3 Maria Divina Pascuzzo,4 Angela D’Angelo,1,2 Pamela Maffioli1 1Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Laboratory of Molecular M...

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Autores principales:	Derosa G, Pascuzzo MD, D'Angelo A, Maffioli P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Ascophyllum Nodosum chromium Fucus Vesiculosus glycemic control Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/03a1cdd0be8b4abba67bdb075d89f7c5
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spelling	oai:doaj.org-article:03a1cdd0be8b4abba67bdb075d89f7c52021-12-02T05:32:48ZAscophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients1178-7007https://doaj.org/article/03a1cdd0be8b4abba67bdb075d89f7c52019-09-01T00:00:00Zhttps://www.dovepress.com/ascophyllum-nodosum-fucus-vesiculosus-and-chromium-picolinate-nutraceu-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Giuseppe Derosa,1–3 Maria Divina Pascuzzo,4 Angela D’Angelo,1,2 Pamela Maffioli1 1Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy; 3Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 4Ambulatory Center ASL Torino 4 and ASL Città Di Torino, Torino, ItalyCorrespondence: Giuseppe DerosaDepartment of Internal Medicine and Therapeutics, University of Pavia, and Fondazione IRCCS Policlinico San Matteo, P.le C. Golgi, 2, Pavia 27100, ItalyTel +39 038 252 6217Fax +39 038 252 6259Email giuseppe.derosa@unipv.itAim: To evaluate the actions of a combination of polifenolic composition (extracted from Ascophyllum Nodosum and Fucus Vesiculosus, InSea2®) and chromium picolinate compared to placebo in addition to previously taken anti-diabetic therapy in patients with type 2 diabetes.Methods: 175 Caucasian patients with type 2 diabetes were randomized to take nutraceutical combination or placebo for 6 months. One hundred and sixty-four cases completed the study. At baseline and after 6 months, glyco-metabolic control and lipid profile were evaluated.Results: Glycated hemoglobin was significantly reduced by the nutraceutical combination, but not by placebo, both compared to baseline (p<0.05), and compared to placebo (p<0.05). A similar trend was recorded for fasting plasma glucose (FPG) [−23.5% (p<0.01) vs baseline, and −18.0% (p<0.01) vs placebo] and post-prandial glucose (PPG) [−17.1% (p<0.01) vs baseline, and −11.1% (p<0.05) vs placebo]. No variations of lipid profile were recorded compared to baseline, even if it seems to observe a reduction trend of triglycerides level in the nutraceutical group.Conclusion: In conclusion, a nutraceutical combination of polifenolic composition and chromium picolinate in addition to previously taken anti-diabetic therapy can be helpful in reducing glycated hemoglobin in patients with type 2 diabetes mellitus.Keywords: Ascophyllum Nodosum, chromium, Fucus Vesiculosus, glycemic controlDerosa GPascuzzo MDD'Angelo AMaffioli PDove Medical PressarticleAscophyllum NodosumchromiumFucus Vesiculosusglycemic controlSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1861-1865 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ascophyllum Nodosum chromium Fucus Vesiculosus glycemic control Specialties of internal medicine RC581-951
spellingShingle	Ascophyllum Nodosum chromium Fucus Vesiculosus glycemic control Specialties of internal medicine RC581-951 Derosa G Pascuzzo MD D'Angelo A Maffioli P Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients
description	Giuseppe Derosa,1–3 Maria Divina Pascuzzo,4 Angela D’Angelo,1,2 Pamela Maffioli1 1Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy; 3Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 4Ambulatory Center ASL Torino 4 and ASL Città Di Torino, Torino, ItalyCorrespondence: Giuseppe DerosaDepartment of Internal Medicine and Therapeutics, University of Pavia, and Fondazione IRCCS Policlinico San Matteo, P.le C. Golgi, 2, Pavia 27100, ItalyTel +39 038 252 6217Fax +39 038 252 6259Email giuseppe.derosa@unipv.itAim: To evaluate the actions of a combination of polifenolic composition (extracted from Ascophyllum Nodosum and Fucus Vesiculosus, InSea2®) and chromium picolinate compared to placebo in addition to previously taken anti-diabetic therapy in patients with type 2 diabetes.Methods: 175 Caucasian patients with type 2 diabetes were randomized to take nutraceutical combination or placebo for 6 months. One hundred and sixty-four cases completed the study. At baseline and after 6 months, glyco-metabolic control and lipid profile were evaluated.Results: Glycated hemoglobin was significantly reduced by the nutraceutical combination, but not by placebo, both compared to baseline (p<0.05), and compared to placebo (p<0.05). A similar trend was recorded for fasting plasma glucose (FPG) [−23.5% (p<0.01) vs baseline, and −18.0% (p<0.01) vs placebo] and post-prandial glucose (PPG) [−17.1% (p<0.01) vs baseline, and −11.1% (p<0.05) vs placebo]. No variations of lipid profile were recorded compared to baseline, even if it seems to observe a reduction trend of triglycerides level in the nutraceutical group.Conclusion: In conclusion, a nutraceutical combination of polifenolic composition and chromium picolinate in addition to previously taken anti-diabetic therapy can be helpful in reducing glycated hemoglobin in patients with type 2 diabetes mellitus.Keywords: Ascophyllum Nodosum, chromium, Fucus Vesiculosus, glycemic control
format	article
author	Derosa G Pascuzzo MD D'Angelo A Maffioli P
author_facet	Derosa G Pascuzzo MD D'Angelo A Maffioli P
author_sort	Derosa G
title	Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients
title_short	Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients
title_full	Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients
title_fullStr	Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients
title_full_unstemmed	Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients
title_sort	ascophyllum nodosum, fucus vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/03a1cdd0be8b4abba67bdb075d89f7c5
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Ascophyllum Nodosum, Fucus Vesiculosus and chromium picolinate nutraceutical composition can help to treat type 2 diabetic patients

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