Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering

5-Hydroxymethylfurfural (HMF) can be transformed to a range of industrially useful derivatives, such as 2,5-diformylfuran (DFF), but the reactions needed for efficient industrial production are hindered by several issues. Here, the authors perform reaction and enzyme engineering resulting in a galac...

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Autores principales:	William R. Birmingham, Asbjørn Toftgaard Pedersen, Mafalda Dias Gomes, Mathias Bøje Madsen, Michael Breuer, John M. Woodley, Nicholas J. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03a60559d47e46bf830100c68c44399f
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spelling	oai:doaj.org-article:03a60559d47e46bf830100c68c44399f2021-12-02T17:08:26ZToward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering10.1038/s41467-021-25034-32041-1723https://doaj.org/article/03a60559d47e46bf830100c68c44399f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25034-3https://doaj.org/toc/2041-17235-Hydroxymethylfurfural (HMF) can be transformed to a range of industrially useful derivatives, such as 2,5-diformylfuran (DFF), but the reactions needed for efficient industrial production are hindered by several issues. Here, the authors perform reaction and enzyme engineering resulting in a galactose oxidase variant with high activity towards HMF, improved oxygen binding and high productivity.William R. BirminghamAsbjørn Toftgaard PedersenMafalda Dias GomesMathias Bøje MadsenMichael BreuerJohn M. WoodleyNicholas J. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William R. Birmingham Asbjørn Toftgaard Pedersen Mafalda Dias Gomes Mathias Bøje Madsen Michael Breuer John M. Woodley Nicholas J. Turner Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering
description	5-Hydroxymethylfurfural (HMF) can be transformed to a range of industrially useful derivatives, such as 2,5-diformylfuran (DFF), but the reactions needed for efficient industrial production are hindered by several issues. Here, the authors perform reaction and enzyme engineering resulting in a galactose oxidase variant with high activity towards HMF, improved oxygen binding and high productivity.
format	article
author	William R. Birmingham Asbjørn Toftgaard Pedersen Mafalda Dias Gomes Mathias Bøje Madsen Michael Breuer John M. Woodley Nicholas J. Turner
author_facet	William R. Birmingham Asbjørn Toftgaard Pedersen Mafalda Dias Gomes Mathias Bøje Madsen Michael Breuer John M. Woodley Nicholas J. Turner
author_sort	William R. Birmingham
title	Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering
title_short	Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering
title_full	Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering
title_fullStr	Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering
title_full_unstemmed	Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering
title_sort	toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/03a60559d47e46bf830100c68c44399f
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Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering

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