Prevalence of migraine in adults with celiac disease: A case control cross-sectional study

<h4>Aim</h4> Celiac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially migraine, and compare it with healthy individuals. <h...

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Autores principales:	Mohammad M. Fanaeian, Nazanin Alibeik, Azita Ganji, Hafez Fakheri, Golnaz Ekhlasi, Bijan Shahbazkhani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03a62d1c81104c84ba9fbade45cea329
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spelling	oai:doaj.org-article:03a62d1c81104c84ba9fbade45cea3292021-11-25T06:13:53ZPrevalence of migraine in adults with celiac disease: A case control cross-sectional study1932-6203https://doaj.org/article/03a62d1c81104c84ba9fbade45cea3292021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598245/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aim</h4> Celiac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially migraine, and compare it with healthy individuals. <h4>Methods</h4> We compared 1000 celiac subjects (CS) registered at our celiac center with the control group for headache-based on International Classification of Headache Disorders, third edition criteria and their GI symptoms. Besides, CS with migraine and non-migrainous headache were compared in terms of GI symptoms and accompanied conditions. <h4>Results</h4> Headache was more common in CS than controls (34% vs 27% respectively, P value<0.001) and more prevalent in females (71.9% in females vs 28% in males, P value = 0.004). Moreover, the prevalence of migraine in CS was higher than controls (20.7 vs 11.9% respectively, P value<0.001). Furthermore, migraine was more prevalent in females with CD (80% in females vs 19% in males, P value = 0.033), and often without aura (76%). Abdominal pain (76.9%, P value = 0.025), diarrhea (54.9%, P value = 0.002), and constipation (42.9%, P value = 0.011) were the most common GI symptoms in CS with headache and more prevalent in CS with migraine. Conversely, type 1 diabetes mellitus was less common in CS with migraine than in CS with non-migrainous headache. (P value = 0.001). On multivariate logistic regression analysis, female sex (OR 1.50, 95%CI 1.22–1.83, P value < 0.001), and CD (OR 1.36, 95%CI 1.12–1.65, P value = 0.002) were independent predictors of headache, whereas age more than 60 years (OR 0.70, 95%CI 0.50–0.97, P value = 0.032) had a protective effect. <h4>Conclusion</h4> Headache especially migraine is more prevalent in CS than healthy controls. In addition, abdominal pain, diarrhea, and constipation are more common in CS with migraine than in CS with non-migrainous headaches. Therefore, evaluation of CD in patients with migraine and these simultaneous GI symptoms seems reasonable.Mohammad M. FanaeianNazanin AlibeikAzita GanjiHafez FakheriGolnaz EkhlasiBijan ShahbazkhaniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad M. Fanaeian Nazanin Alibeik Azita Ganji Hafez Fakheri Golnaz Ekhlasi Bijan Shahbazkhani Prevalence of migraine in adults with celiac disease: A case control cross-sectional study
description	<h4>Aim</h4> Celiac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially migraine, and compare it with healthy individuals. <h4>Methods</h4> We compared 1000 celiac subjects (CS) registered at our celiac center with the control group for headache-based on International Classification of Headache Disorders, third edition criteria and their GI symptoms. Besides, CS with migraine and non-migrainous headache were compared in terms of GI symptoms and accompanied conditions. <h4>Results</h4> Headache was more common in CS than controls (34% vs 27% respectively, P value<0.001) and more prevalent in females (71.9% in females vs 28% in males, P value = 0.004). Moreover, the prevalence of migraine in CS was higher than controls (20.7 vs 11.9% respectively, P value<0.001). Furthermore, migraine was more prevalent in females with CD (80% in females vs 19% in males, P value = 0.033), and often without aura (76%). Abdominal pain (76.9%, P value = 0.025), diarrhea (54.9%, P value = 0.002), and constipation (42.9%, P value = 0.011) were the most common GI symptoms in CS with headache and more prevalent in CS with migraine. Conversely, type 1 diabetes mellitus was less common in CS with migraine than in CS with non-migrainous headache. (P value = 0.001). On multivariate logistic regression analysis, female sex (OR 1.50, 95%CI 1.22–1.83, P value < 0.001), and CD (OR 1.36, 95%CI 1.12–1.65, P value = 0.002) were independent predictors of headache, whereas age more than 60 years (OR 0.70, 95%CI 0.50–0.97, P value = 0.032) had a protective effect. <h4>Conclusion</h4> Headache especially migraine is more prevalent in CS than healthy controls. In addition, abdominal pain, diarrhea, and constipation are more common in CS with migraine than in CS with non-migrainous headaches. Therefore, evaluation of CD in patients with migraine and these simultaneous GI symptoms seems reasonable.
format	article
author	Mohammad M. Fanaeian Nazanin Alibeik Azita Ganji Hafez Fakheri Golnaz Ekhlasi Bijan Shahbazkhani
author_facet	Mohammad M. Fanaeian Nazanin Alibeik Azita Ganji Hafez Fakheri Golnaz Ekhlasi Bijan Shahbazkhani
author_sort	Mohammad M. Fanaeian
title	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study
title_short	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study
title_full	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study
title_fullStr	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study
title_full_unstemmed	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study
title_sort	prevalence of migraine in adults with celiac disease: a case control cross-sectional study
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/03a62d1c81104c84ba9fbade45cea329
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Prevalence of migraine in adults with celiac disease: A case control cross-sectional study

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