Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibition
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Nature Portfolio
2019
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oai:doaj.org-article:03a72eb189654119bb1c127366a2d06f2021-12-02T15:35:37ZTargeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells10.1038/s41467-019-09309-42041-1723https://doaj.org/article/03a72eb189654119bb1c127366a2d06f2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09309-4https://doaj.org/toc/2041-1723The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibitionEvelyne Lima-FernandesAlex MurisonTiago da Silva MedinaYadong WangAnqi MaCherry LeungGenna M. LucianiJennifer HaynesAaron PollettConstanze ZellerShili DuanAntonija KresoDalia Barsyte-LovejoyBradly G. WoutersJian JinDaniel D. De CarvalhoMathieu LupienCheryl H. ArrowsmithCatherine A. O’BrienNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Evelyne Lima-Fernandes Alex Murison Tiago da Silva Medina Yadong Wang Anqi Ma Cherry Leung Genna M. Luciani Jennifer Haynes Aaron Pollett Constanze Zeller Shili Duan Antonija Kreso Dalia Barsyte-Lovejoy Bradly G. Wouters Jian Jin Daniel D. De Carvalho Mathieu Lupien Cheryl H. Arrowsmith Catherine A. O’Brien Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells |
| description |
The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiating cells, and can be targeted by EZH2 inhibition |
| format |
article |
| author |
Evelyne Lima-Fernandes Alex Murison Tiago da Silva Medina Yadong Wang Anqi Ma Cherry Leung Genna M. Luciani Jennifer Haynes Aaron Pollett Constanze Zeller Shili Duan Antonija Kreso Dalia Barsyte-Lovejoy Bradly G. Wouters Jian Jin Daniel D. De Carvalho Mathieu Lupien Cheryl H. Arrowsmith Catherine A. O’Brien |
| author_facet |
Evelyne Lima-Fernandes Alex Murison Tiago da Silva Medina Yadong Wang Anqi Ma Cherry Leung Genna M. Luciani Jennifer Haynes Aaron Pollett Constanze Zeller Shili Duan Antonija Kreso Dalia Barsyte-Lovejoy Bradly G. Wouters Jian Jin Daniel D. De Carvalho Mathieu Lupien Cheryl H. Arrowsmith Catherine A. O’Brien |
| author_sort |
Evelyne Lima-Fernandes |
| title |
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells |
| title_short |
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells |
| title_full |
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells |
| title_fullStr |
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells |
| title_full_unstemmed |
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells |
| title_sort |
targeting bivalency de-represses indian hedgehog and inhibits self-renewal of colorectal cancer-initiating cells |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/03a72eb189654119bb1c127366a2d06f |
| work_keys_str_mv |
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| _version_ |
1718386453005729792 |