Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment

Despite the importance of pain as a warning physiological system, chronic neuropathic pain is frequently caused by damage in the nervous system, followed by persistence over a long period, even in the absence of dangerous stimuli or after healing of injuries. Chronic neuropathic pain affects hundred...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Raquel Maria P. Campos, Andrey F. L. Aguiar, Yolanda Paes-Colli, Priscila Martins Pinheiro Trindade, Bruna K. Ferreira, Ricardo A. de Melo Reis, Luzia S. Sampaio
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neuropathic pain endocannabinoid cannabidiol THC cannabis Physiology QP1-981
Acceso en línea:	https://doaj.org/article/03a98ec98f30460d980efc6059e2c121
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03a98ec98f30460d980efc6059e2c121
record_format	dspace
spelling	oai:doaj.org-article:03a98ec98f30460d980efc6059e2c1212021-12-01T18:13:53ZCannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment1664-042X10.3389/fphys.2021.785176https://doaj.org/article/03a98ec98f30460d980efc6059e2c1212021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.785176/fullhttps://doaj.org/toc/1664-042XDespite the importance of pain as a warning physiological system, chronic neuropathic pain is frequently caused by damage in the nervous system, followed by persistence over a long period, even in the absence of dangerous stimuli or after healing of injuries. Chronic neuropathic pain affects hundreds of millions of adults worldwide, creating a direct impact on quality of life. This pathology has been extensively characterized concerning its cellular and molecular mechanisms, and the endocannabinoid system (eCS) is widely recognized as pivotal in the development of chronic neuropathic pain. Scientific evidence has supported that phyto-, synthetic and endocannabinoids are efficient for pain management, while strong data arise from the therapeutic use of Cannabis-derived products. The use of medicinal Cannabis products is directed toward not only relieving symptoms of chronic pain, but also improving several aspects of patients’ welfare. Here, we review the involvement of eCS, along with other cellular and molecular elements, in chronic neuropathic pain pathology and how this system can be targeted for pain management.Raquel Maria P. CamposAndrey F. L. AguiarYolanda Paes-ColliPriscila Martins Pinheiro TrindadeBruna K. FerreiraRicardo A. de Melo ReisLuzia S. SampaioFrontiers Media S.A.articleneuropathic painendocannabinoidcannabidiolTHCcannabisPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuropathic pain endocannabinoid cannabidiol THC cannabis Physiology QP1-981
spellingShingle	neuropathic pain endocannabinoid cannabidiol THC cannabis Physiology QP1-981 Raquel Maria P. Campos Andrey F. L. Aguiar Yolanda Paes-Colli Priscila Martins Pinheiro Trindade Bruna K. Ferreira Ricardo A. de Melo Reis Luzia S. Sampaio Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
description	Despite the importance of pain as a warning physiological system, chronic neuropathic pain is frequently caused by damage in the nervous system, followed by persistence over a long period, even in the absence of dangerous stimuli or after healing of injuries. Chronic neuropathic pain affects hundreds of millions of adults worldwide, creating a direct impact on quality of life. This pathology has been extensively characterized concerning its cellular and molecular mechanisms, and the endocannabinoid system (eCS) is widely recognized as pivotal in the development of chronic neuropathic pain. Scientific evidence has supported that phyto-, synthetic and endocannabinoids are efficient for pain management, while strong data arise from the therapeutic use of Cannabis-derived products. The use of medicinal Cannabis products is directed toward not only relieving symptoms of chronic pain, but also improving several aspects of patients’ welfare. Here, we review the involvement of eCS, along with other cellular and molecular elements, in chronic neuropathic pain pathology and how this system can be targeted for pain management.
format	article
author	Raquel Maria P. Campos Andrey F. L. Aguiar Yolanda Paes-Colli Priscila Martins Pinheiro Trindade Bruna K. Ferreira Ricardo A. de Melo Reis Luzia S. Sampaio
author_facet	Raquel Maria P. Campos Andrey F. L. Aguiar Yolanda Paes-Colli Priscila Martins Pinheiro Trindade Bruna K. Ferreira Ricardo A. de Melo Reis Luzia S. Sampaio
author_sort	Raquel Maria P. Campos
title	Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
title_short	Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
title_full	Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
title_fullStr	Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
title_full_unstemmed	Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment
title_sort	cannabinoid therapeutics in chronic neuropathic pain: from animal research to human treatment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/03a98ec98f30460d980efc6059e2c121
work_keys_str_mv	AT raquelmariapcampos cannabinoidtherapeuticsinchronicneuropathicpainfromanimalresearchtohumantreatment AT andreyflaguiar cannabinoidtherapeuticsinchronicneuropathicpainfromanimalresearchtohumantreatment AT yolandapaescolli cannabinoidtherapeuticsinchronicneuropathicpainfromanimalresearchtohumantreatment AT priscilamartinspinheirotrindade cannabinoidtherapeuticsinchronicneuropathicpainfromanimalresearchtohumantreatment AT brunakferreira cannabinoidtherapeuticsinchronicneuropathicpainfromanimalresearchtohumantreatment AT ricardoademeloreis cannabinoidtherapeuticsinchronicneuropathicpainfromanimalresearchtohumantreatment AT luziassampaio cannabinoidtherapeuticsinchronicneuropathicpainfromanimalresearchtohumantreatment
_version_	1718404672401702912

Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment

Ejemplares similares