Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods

Abstract Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis could be realized by tailoring the appropriate structural properties of gold nano rods (GNRs) that could precisely modulate cell deat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fulei Zhang, Yi Hou, Minhui Zhu, Bo Deng, Mengxin Zhao, Xiandi Zhu, Yun Sun, Di Chen, Cheng Jiang, Liming Wang, Chunying Chen, Huaiwen Chen, Han Chen, Hongliang Zheng, Wei Li
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cancer therapy cell death pathway gold nanorods surface molecule density Science Q
Acceso en línea:	https://doaj.org/article/03aa18f312214643b4991d824916fb5a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03aa18f312214643b4991d824916fb5a
record_format	dspace
spelling	oai:doaj.org-article:03aa18f312214643b4991d824916fb5a2021-11-17T08:40:31ZDeath Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods2198-384410.1002/advs.202102666https://doaj.org/article/03aa18f312214643b4991d824916fb5a2021-11-01T00:00:00Zhttps://doi.org/10.1002/advs.202102666https://doaj.org/toc/2198-3844Abstract Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis could be realized by tailoring the appropriate structural properties of gold nano rods (GNRs) that could precisely modulate cell death pathways. Herein, the intracellular interaction between GNRs and organelles is monitored and it is found that lysosomes dominates necrosis/apoptosis evoking. Then the surface molecule density of GNRs, which is first defined as ρsurf. molecule (Nsurf. molecules/(a × π × Diameter × Length)), mediates lysosome activities as the membrane permeabilization (LMP), the Cathepsin B and D release, the cross‐talk between lysosome and different organelles, which selectively evokes apoptosis or necrosis and the production of TNF‐α from macrophages. GNRs with small ρsurf. molecule mainly induce apoptosis, while with large ρsurf. molecule they greatly contribute to necrosis. Interestingly, necrosis can be suppressed by GNRs with higher ρsurf. molecule due to the overexpression of key protease caspase 8, which cleaves the RIP1‐RIP3 complex and activates caspase 3 followed by necrosis to apoptosis transition. This investigation indicates that the ρsurf. molecule greatly affects the utility of nanomaterials and different structural properties of nanomaterials have different implications in clinics.Fulei ZhangYi HouMinhui ZhuBo DengMengxin ZhaoXiandi ZhuYun SunDi ChenCheng JiangLiming WangChunying ChenHuaiwen ChenHan ChenHongliang ZhengWei LiWileyarticlecancer therapycell death pathwaygold nanorodssurface molecule densityScienceQENAdvanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer therapy cell death pathway gold nanorods surface molecule density Science Q
spellingShingle	cancer therapy cell death pathway gold nanorods surface molecule density Science Q Fulei Zhang Yi Hou Minhui Zhu Bo Deng Mengxin Zhao Xiandi Zhu Yun Sun Di Chen Cheng Jiang Liming Wang Chunying Chen Huaiwen Chen Han Chen Hongliang Zheng Wei Li Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods
description	Abstract Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis could be realized by tailoring the appropriate structural properties of gold nano rods (GNRs) that could precisely modulate cell death pathways. Herein, the intracellular interaction between GNRs and organelles is monitored and it is found that lysosomes dominates necrosis/apoptosis evoking. Then the surface molecule density of GNRs, which is first defined as ρsurf. molecule (Nsurf. molecules/(a × π × Diameter × Length)), mediates lysosome activities as the membrane permeabilization (LMP), the Cathepsin B and D release, the cross‐talk between lysosome and different organelles, which selectively evokes apoptosis or necrosis and the production of TNF‐α from macrophages. GNRs with small ρsurf. molecule mainly induce apoptosis, while with large ρsurf. molecule they greatly contribute to necrosis. Interestingly, necrosis can be suppressed by GNRs with higher ρsurf. molecule due to the overexpression of key protease caspase 8, which cleaves the RIP1‐RIP3 complex and activates caspase 3 followed by necrosis to apoptosis transition. This investigation indicates that the ρsurf. molecule greatly affects the utility of nanomaterials and different structural properties of nanomaterials have different implications in clinics.
format	article
author	Fulei Zhang Yi Hou Minhui Zhu Bo Deng Mengxin Zhao Xiandi Zhu Yun Sun Di Chen Cheng Jiang Liming Wang Chunying Chen Huaiwen Chen Han Chen Hongliang Zheng Wei Li
author_facet	Fulei Zhang Yi Hou Minhui Zhu Bo Deng Mengxin Zhao Xiandi Zhu Yun Sun Di Chen Cheng Jiang Liming Wang Chunying Chen Huaiwen Chen Han Chen Hongliang Zheng Wei Li
author_sort	Fulei Zhang
title	Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods
title_short	Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods
title_full	Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods
title_fullStr	Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods
title_full_unstemmed	Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods
title_sort	death pathways of cancer cells modulated by surface molecule density on gold nanorods
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/03aa18f312214643b4991d824916fb5a
work_keys_str_mv	AT fuleizhang deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT yihou deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT minhuizhu deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT bodeng deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT mengxinzhao deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT xiandizhu deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT yunsun deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT dichen deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT chengjiang deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT limingwang deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT chunyingchen deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT huaiwenchen deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT hanchen deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT hongliangzheng deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods AT weili deathpathwaysofcancercellsmodulatedbysurfacemoleculedensityongoldnanorods
_version_	1718425650545557504

Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods

Ejemplares similares