Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response

The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphorylates phospholamban to enhance diastolic relaxation...

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Autores principales:	Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
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spelling	oai:doaj.org-article:03ace94ba067478fa8463d2ab1ace41b2021-12-02T15:34:59ZDisulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response10.1038/ncomms131872041-1723https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13187https://doaj.org/toc/2041-1723The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphorylates phospholamban to enhance diastolic relaxation in mice.Jenna ScotcherOleksandra PrysyazhnaAndrii BoguslavskyiKornel KistamasNatasha HadgraftEva D. MartinJenny WorthingtonOlena RudykPedro Rodriguez CutillasFriederike CuelloMichael J. ShattockMichael S. MarberMaria R. ConteAdam GreensteinDavid J. GreensmithLuigi VenetucciJohn F. TimmsPhilip EatonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jenna Scotcher Oleksandra Prysyazhna Andrii Boguslavskyi Kornel Kistamas Natasha Hadgraft Eva D. Martin Jenny Worthington Olena Rudyk Pedro Rodriguez Cutillas Friederike Cuello Michael J. Shattock Michael S. Marber Maria R. Conte Adam Greenstein David J. Greensmith Luigi Venetucci John F. Timms Philip Eaton Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
description	The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphorylates phospholamban to enhance diastolic relaxation in mice.
format	article
author	Jenna Scotcher Oleksandra Prysyazhna Andrii Boguslavskyi Kornel Kistamas Natasha Hadgraft Eva D. Martin Jenny Worthington Olena Rudyk Pedro Rodriguez Cutillas Friederike Cuello Michael J. Shattock Michael S. Marber Maria R. Conte Adam Greenstein David J. Greensmith Luigi Venetucci John F. Timms Philip Eaton
author_facet	Jenna Scotcher Oleksandra Prysyazhna Andrii Boguslavskyi Kornel Kistamas Natasha Hadgraft Eva D. Martin Jenny Worthington Olena Rudyk Pedro Rodriguez Cutillas Friederike Cuello Michael J. Shattock Michael S. Marber Maria R. Conte Adam Greenstein David J. Greensmith Luigi Venetucci John F. Timms Philip Eaton
author_sort	Jenna Scotcher
title	Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
title_short	Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
title_full	Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
title_fullStr	Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
title_full_unstemmed	Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
title_sort	disulfide-activated protein kinase g iα regulates cardiac diastolic relaxation and fine-tunes the frank–starling response
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
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Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response

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