3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

Abstract Carbonic anhydrase IX (CA9) expression level has been considered as a poor prognostic factor in hepatocellular carcinoma (HCC) patients. However, the judging criteria of CA9 level is hard to define for potential clinical applications. Unlike CA9 expression level, CA9 polymorphism is poorly...

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Autores principales:	Kuo-Tai Hua, Yu-Fan Liu, Chia-Lang Hsu, Tsu-Yao Cheng, Ching-Yao Yang, Jeng-Shou Chang, Wei-Jiunn Lee, Michael Hsiao, Hsueh-Fen Juan, Ming-Hsien Chien, Shun-Fa Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03afcea16ef047d29b8d84a60d7d9667
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spelling	oai:doaj.org-article:03afcea16ef047d29b8d84a60d7d96672021-12-02T15:05:47Z3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma10.1038/s41598-017-04732-32045-2322https://doaj.org/article/03afcea16ef047d29b8d84a60d7d96672017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04732-3https://doaj.org/toc/2045-2322Abstract Carbonic anhydrase IX (CA9) expression level has been considered as a poor prognostic factor in hepatocellular carcinoma (HCC) patients. However, the judging criteria of CA9 level is hard to define for potential clinical applications. Unlike CA9 expression level, CA9 polymorphism is poorly documented in HCC. Here, we found that people carry A allele at CA9 rs1048638, a 3′UTR SNP, has higher risk of HCC. rs1048638-CA correlates with advanced stages, larger tumor sizes, more vascular invasion, and shorter survival of HCC patients. A allele at CA9 rs1048638 impairs miR-34a, a tumor suppressor miRNA in HCC, binding to CA9 3′UTR and desensitizes CA9 mRNA to miR-34a-dependent RNA degradation. CA9 expression levels were also correlated with miR-34a levels and rs1048638 genotypes in HCC patients. rs1048638 influences HCC risk and progression through effects on miR-34a-targeted CA9 expression in HCC. In conclusion, genetic variations of the CA9 3′UTR play important roles in regulating CA9 expression and cancer progression, which is a novel determinant and target for HCC metastasis and prognosis.Kuo-Tai HuaYu-Fan LiuChia-Lang HsuTsu-Yao ChengChing-Yao YangJeng-Shou ChangWei-Jiunn LeeMichael HsiaoHsueh-Fen JuanMing-Hsien ChienShun-Fa YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuo-Tai Hua Yu-Fan Liu Chia-Lang Hsu Tsu-Yao Cheng Ching-Yao Yang Jeng-Shou Chang Wei-Jiunn Lee Michael Hsiao Hsueh-Fen Juan Ming-Hsien Chien Shun-Fa Yang 3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
description	Abstract Carbonic anhydrase IX (CA9) expression level has been considered as a poor prognostic factor in hepatocellular carcinoma (HCC) patients. However, the judging criteria of CA9 level is hard to define for potential clinical applications. Unlike CA9 expression level, CA9 polymorphism is poorly documented in HCC. Here, we found that people carry A allele at CA9 rs1048638, a 3′UTR SNP, has higher risk of HCC. rs1048638-CA correlates with advanced stages, larger tumor sizes, more vascular invasion, and shorter survival of HCC patients. A allele at CA9 rs1048638 impairs miR-34a, a tumor suppressor miRNA in HCC, binding to CA9 3′UTR and desensitizes CA9 mRNA to miR-34a-dependent RNA degradation. CA9 expression levels were also correlated with miR-34a levels and rs1048638 genotypes in HCC patients. rs1048638 influences HCC risk and progression through effects on miR-34a-targeted CA9 expression in HCC. In conclusion, genetic variations of the CA9 3′UTR play important roles in regulating CA9 expression and cancer progression, which is a novel determinant and target for HCC metastasis and prognosis.
format	article
author	Kuo-Tai Hua Yu-Fan Liu Chia-Lang Hsu Tsu-Yao Cheng Ching-Yao Yang Jeng-Shou Chang Wei-Jiunn Lee Michael Hsiao Hsueh-Fen Juan Ming-Hsien Chien Shun-Fa Yang
author_facet	Kuo-Tai Hua Yu-Fan Liu Chia-Lang Hsu Tsu-Yao Cheng Ching-Yao Yang Jeng-Shou Chang Wei-Jiunn Lee Michael Hsiao Hsueh-Fen Juan Ming-Hsien Chien Shun-Fa Yang
author_sort	Kuo-Tai Hua
title	3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
title_short	3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
title_full	3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
title_fullStr	3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
title_full_unstemmed	3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma
title_sort	3′utr polymorphisms of carbonic anhydrase ix determine the mir-34a targeting efficiency and prognosis of hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/03afcea16ef047d29b8d84a60d7d9667
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3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

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