Structural basis for itraconazole-mediated NPC1 inhibition

Niemann-Pick C1 (NPC1) exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes and comporses a Sterol-Sensing Domain (SSD). Here authors report a cryo-EM structure of human NPC1 bound to itraconazole which reveals how this binding site in the center of NPC1 blocks a putative lumenal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tao Long, Xiaofeng Qi, Abdirahman Hassan, Qiren Liang, Jef K. De Brabander, Xiaochun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03b0248f1a404455a6b9ecf783cbaf92
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03b0248f1a404455a6b9ecf783cbaf92
record_format	dspace
spelling	oai:doaj.org-article:03b0248f1a404455a6b9ecf783cbaf922021-12-02T15:39:23ZStructural basis for itraconazole-mediated NPC1 inhibition10.1038/s41467-019-13917-52041-1723https://doaj.org/article/03b0248f1a404455a6b9ecf783cbaf922020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13917-5https://doaj.org/toc/2041-1723Niemann-Pick C1 (NPC1) exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes and comporses a Sterol-Sensing Domain (SSD). Here authors report a cryo-EM structure of human NPC1 bound to itraconazole which reveals how this binding site in the center of NPC1 blocks a putative lumenal tunnel linked to the SSD.Tao LongXiaofeng QiAbdirahman HassanQiren LiangJef K. De BrabanderXiaochun LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Long Xiaofeng Qi Abdirahman Hassan Qiren Liang Jef K. De Brabander Xiaochun Li Structural basis for itraconazole-mediated NPC1 inhibition
description	Niemann-Pick C1 (NPC1) exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes and comporses a Sterol-Sensing Domain (SSD). Here authors report a cryo-EM structure of human NPC1 bound to itraconazole which reveals how this binding site in the center of NPC1 blocks a putative lumenal tunnel linked to the SSD.
format	article
author	Tao Long Xiaofeng Qi Abdirahman Hassan Qiren Liang Jef K. De Brabander Xiaochun Li
author_facet	Tao Long Xiaofeng Qi Abdirahman Hassan Qiren Liang Jef K. De Brabander Xiaochun Li
author_sort	Tao Long
title	Structural basis for itraconazole-mediated NPC1 inhibition
title_short	Structural basis for itraconazole-mediated NPC1 inhibition
title_full	Structural basis for itraconazole-mediated NPC1 inhibition
title_fullStr	Structural basis for itraconazole-mediated NPC1 inhibition
title_full_unstemmed	Structural basis for itraconazole-mediated NPC1 inhibition
title_sort	structural basis for itraconazole-mediated npc1 inhibition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/03b0248f1a404455a6b9ecf783cbaf92
work_keys_str_mv	AT taolong structuralbasisforitraconazolemediatednpc1inhibition AT xiaofengqi structuralbasisforitraconazolemediatednpc1inhibition AT abdirahmanhassan structuralbasisforitraconazolemediatednpc1inhibition AT qirenliang structuralbasisforitraconazolemediatednpc1inhibition AT jefkdebrabander structuralbasisforitraconazolemediatednpc1inhibition AT xiaochunli structuralbasisforitraconazolemediatednpc1inhibition
_version_	1718385911547297792

Structural basis for itraconazole-mediated NPC1 inhibition

Ejemplares similares