Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

Cancer immunotherapy is ineffective in a subset of patients. Here the authors show that, in a mouse model of melanoma, resistance to immune checkpoint inhibitors relies on loss of tumor-specific T cells through FasL-mediated apoptosis triggered by polymorphonuclear-myeloid-derived suppressor cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jingjing Zhu, Céline G. Powis de Tenbossche, Stefania Cané, Didier Colau, Nicolas van Baren, Christophe Lurquin, Anne-Marie Schmitt-Verhulst, Peter Liljeström, Catherine Uyttenhove, Benoit J. Van den Eynde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03b05d3e6ab641c1b1de96121c6dfbee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03b05d3e6ab641c1b1de96121c6dfbee
record_format	dspace
spelling	oai:doaj.org-article:03b05d3e6ab641c1b1de96121c6dfbee2021-12-02T15:38:58ZResistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes10.1038/s41467-017-00784-12041-1723https://doaj.org/article/03b05d3e6ab641c1b1de96121c6dfbee2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00784-1https://doaj.org/toc/2041-1723Cancer immunotherapy is ineffective in a subset of patients. Here the authors show that, in a mouse model of melanoma, resistance to immune checkpoint inhibitors relies on loss of tumor-specific T cells through FasL-mediated apoptosis triggered by polymorphonuclear-myeloid-derived suppressor cells.Jingjing ZhuCéline G. Powis de TenbosscheStefania CanéDidier ColauNicolas van BarenChristophe LurquinAnne-Marie Schmitt-VerhulstPeter LiljeströmCatherine UyttenhoveBenoit J. Van den EyndeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingjing Zhu Céline G. Powis de Tenbossche Stefania Cané Didier Colau Nicolas van Baren Christophe Lurquin Anne-Marie Schmitt-Verhulst Peter Liljeström Catherine Uyttenhove Benoit J. Van den Eynde Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
description	Cancer immunotherapy is ineffective in a subset of patients. Here the authors show that, in a mouse model of melanoma, resistance to immune checkpoint inhibitors relies on loss of tumor-specific T cells through FasL-mediated apoptosis triggered by polymorphonuclear-myeloid-derived suppressor cells.
format	article
author	Jingjing Zhu Céline G. Powis de Tenbossche Stefania Cané Didier Colau Nicolas van Baren Christophe Lurquin Anne-Marie Schmitt-Verhulst Peter Liljeström Catherine Uyttenhove Benoit J. Van den Eynde
author_facet	Jingjing Zhu Céline G. Powis de Tenbossche Stefania Cané Didier Colau Nicolas van Baren Christophe Lurquin Anne-Marie Schmitt-Verhulst Peter Liljeström Catherine Uyttenhove Benoit J. Van den Eynde
author_sort	Jingjing Zhu
title	Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
title_short	Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
title_full	Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
title_fullStr	Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
title_full_unstemmed	Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
title_sort	resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/03b05d3e6ab641c1b1de96121c6dfbee
work_keys_str_mv	AT jingjingzhu resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT celinegpowisdetenbossche resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT stefaniacane resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT didiercolau resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT nicolasvanbaren resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT christophelurquin resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT annemarieschmittverhulst resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT peterliljestrom resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT catherineuyttenhove resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes AT benoitjvandeneynde resistancetocancerimmunotherapymediatedbyapoptosisoftumorinfiltratinglymphocytes
_version_	1718385971047694336

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

Ejemplares similares