Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes

Cancer immunotherapy is ineffective in a subset of patients. Here the authors show that, in a mouse model of melanoma, resistance to immune checkpoint inhibitors relies on loss of tumor-specific T cells through FasL-mediated apoptosis triggered by polymorphonuclear-myeloid-derived suppressor cells.

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Detalles Bibliográficos
Autores principales: Jingjing Zhu, Céline G. Powis de Tenbossche, Stefania Cané, Didier Colau, Nicolas van Baren, Christophe Lurquin, Anne-Marie Schmitt-Verhulst, Peter Liljeström, Catherine Uyttenhove, Benoit J. Van den Eynde
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/03b05d3e6ab641c1b1de96121c6dfbee
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