Structural insights of ZIP4 extracellular domain critical for optimal zinc transport

Mutations in the extracellular domain of zinc transporter ZIP4 result in a lethal disorder. Here, the authors report the first crystal structure of ZIP4 extracellular domain, unveiling its unprecedented dimerization and two structural independent subdomains that have crucial roles in zinc transport.

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Detalles Bibliográficos
Autores principales:	Tuo Zhang, Dexin Sui, Jian Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03b65f577cf74bf1b87df7084d170910
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spelling	oai:doaj.org-article:03b65f577cf74bf1b87df7084d1709102021-12-02T17:31:17ZStructural insights of ZIP4 extracellular domain critical for optimal zinc transport10.1038/ncomms119792041-1723https://doaj.org/article/03b65f577cf74bf1b87df7084d1709102016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11979https://doaj.org/toc/2041-1723Mutations in the extracellular domain of zinc transporter ZIP4 result in a lethal disorder. Here, the authors report the first crystal structure of ZIP4 extracellular domain, unveiling its unprecedented dimerization and two structural independent subdomains that have crucial roles in zinc transport.Tuo ZhangDexin SuiJian HuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tuo Zhang Dexin Sui Jian Hu Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
description	Mutations in the extracellular domain of zinc transporter ZIP4 result in a lethal disorder. Here, the authors report the first crystal structure of ZIP4 extracellular domain, unveiling its unprecedented dimerization and two structural independent subdomains that have crucial roles in zinc transport.
format	article
author	Tuo Zhang Dexin Sui Jian Hu
author_facet	Tuo Zhang Dexin Sui Jian Hu
author_sort	Tuo Zhang
title	Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
title_short	Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
title_full	Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
title_fullStr	Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
title_full_unstemmed	Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
title_sort	structural insights of zip4 extracellular domain critical for optimal zinc transport
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/03b65f577cf74bf1b87df7084d170910
work_keys_str_mv	AT tuozhang structuralinsightsofzip4extracellulardomaincriticalforoptimalzinctransport AT dexinsui structuralinsightsofzip4extracellulardomaincriticalforoptimalzinctransport AT jianhu structuralinsightsofzip4extracellulardomaincriticalforoptimalzinctransport
_version_	1718380653111672832

Structural insights of ZIP4 extracellular domain critical for optimal zinc transport

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