Structural insights of ZIP4 extracellular domain critical for optimal zinc transport
Mutations in the extracellular domain of zinc transporter ZIP4 result in a lethal disorder. Here, the authors report the first crystal structure of ZIP4 extracellular domain, unveiling its unprecedented dimerization and two structural independent subdomains that have crucial roles in zinc transport.
Guardado en:
Autores principales: | Tuo Zhang, Dexin Sui, Jian Hu |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
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Materias: | |
Acceso en línea: | https://doaj.org/article/03b65f577cf74bf1b87df7084d170910 |
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