Deep phenotyping unveils hidden traits and genetic relations in subtle mutants

Experimenter scoring of cellular imaging data can be biased. This study describes an automated and unbiased multidimensional phenotyping method that relies on machine learning and complex feature computation of imaging data, and identifies weak alleles affecting synapse morphology in live C. elegans...

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Autores principales:	Adriana San-Miguel, Peri T. Kurshan, Matthew M. Crane, Yuehui Zhao, Patrick T. McGrath, Kang Shen, Hang Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03b8216cade54677a546756f6c9445f4
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spelling	oai:doaj.org-article:03b8216cade54677a546756f6c9445f42021-12-02T14:39:13ZDeep phenotyping unveils hidden traits and genetic relations in subtle mutants10.1038/ncomms129902041-1723https://doaj.org/article/03b8216cade54677a546756f6c9445f42016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms12990https://doaj.org/toc/2041-1723Experimenter scoring of cellular imaging data can be biased. This study describes an automated and unbiased multidimensional phenotyping method that relies on machine learning and complex feature computation of imaging data, and identifies weak alleles affecting synapse morphology in live C. elegans.Adriana San-MiguelPeri T. KurshanMatthew M. CraneYuehui ZhaoPatrick T. McGrathKang ShenHang LuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adriana San-Miguel Peri T. Kurshan Matthew M. Crane Yuehui Zhao Patrick T. McGrath Kang Shen Hang Lu Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
description	Experimenter scoring of cellular imaging data can be biased. This study describes an automated and unbiased multidimensional phenotyping method that relies on machine learning and complex feature computation of imaging data, and identifies weak alleles affecting synapse morphology in live C. elegans.
format	article
author	Adriana San-Miguel Peri T. Kurshan Matthew M. Crane Yuehui Zhao Patrick T. McGrath Kang Shen Hang Lu
author_facet	Adriana San-Miguel Peri T. Kurshan Matthew M. Crane Yuehui Zhao Patrick T. McGrath Kang Shen Hang Lu
author_sort	Adriana San-Miguel
title	Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
title_short	Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
title_full	Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
title_fullStr	Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
title_full_unstemmed	Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
title_sort	deep phenotyping unveils hidden traits and genetic relations in subtle mutants
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/03b8216cade54677a546756f6c9445f4
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Deep phenotyping unveils hidden traits and genetic relations in subtle mutants

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