The topography of mutational processes in breast cancer genomes

The topography of mutational processes in breast cancer genomes

Mutational signatures provide evidence of the mechanism of action of a given mutagen and are found in cancer cells. Here, using 560 breast cancer genomes, the authors demonstrate that mutational signatures are frequently associated with genomic architecture including nucleosome positioning and repli...

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Autores principales: Sandro Morganella, Ludmil B. Alexandrov, Dominik Glodzik, Xueqing Zou, Helen Davies, Johan Staaf, Anieta M. Sieuwerts, Arie B. Brinkman, Sancha Martin, Manasa Ramakrishna, Adam Butler, Hyung-Yong Kim, Åke Borg, Christos Sotiriou, P. Andrew Futreal, Peter J. Campbell, Paul N. Span, Steven Van Laere, Sunil R. Lakhani, Jorunn E. Eyfjord, Alastair M. Thompson, Hendrik G. Stunnenberg, Marc J. van de Vijver, John W. M. Martens, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gu Kong, Gilles Thomas, Julian Sale, Cristina Rada, Michael R. Stratton, Ewan Birney, Serena Nik-Zainal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/03b87554fd0b4b03ab41b2913f616ad7
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spelling oai:doaj.org-article:03b87554fd0b4b03ab41b2913f616ad72021-12-02T16:57:28ZThe topography of mutational processes in breast cancer genomes10.1038/ncomms113832041-1723https://doaj.org/article/03b87554fd0b4b03ab41b2913f616ad72016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11383https://doaj.org/toc/2041-1723Mutational signatures provide evidence of the mechanism of action of a given mutagen and are found in cancer cells. Here, using 560 breast cancer genomes, the authors demonstrate that mutational signatures are frequently associated with genomic architecture including nucleosome positioning and replication timing.Sandro MorganellaLudmil B. AlexandrovDominik GlodzikXueqing ZouHelen DaviesJohan StaafAnieta M. SieuwertsArie B. BrinkmanSancha MartinManasa RamakrishnaAdam ButlerHyung-Yong KimÅke BorgChristos SotiriouP. Andrew FutrealPeter J. CampbellPaul N. SpanSteven Van LaereSunil R. LakhaniJorunn E. EyfjordAlastair M. ThompsonHendrik G. StunnenbergMarc J. van de VijverJohn W. M. MartensAnne-Lise Børresen-DaleAndrea L. RichardsonGu KongGilles ThomasJulian SaleCristina RadaMichael R. StrattonEwan BirneySerena Nik-ZainalNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sandro Morganella
Ludmil B. Alexandrov
Dominik Glodzik
Xueqing Zou
Helen Davies
Johan Staaf
Anieta M. Sieuwerts
Arie B. Brinkman
Sancha Martin
Manasa Ramakrishna
Adam Butler
Hyung-Yong Kim
Åke Borg
Christos Sotiriou
P. Andrew Futreal
Peter J. Campbell
Paul N. Span
Steven Van Laere
Sunil R. Lakhani
Jorunn E. Eyfjord
Alastair M. Thompson
Hendrik G. Stunnenberg
Marc J. van de Vijver
John W. M. Martens
Anne-Lise Børresen-Dale
Andrea L. Richardson
Gu Kong
Gilles Thomas
Julian Sale
Cristina Rada
Michael R. Stratton
Ewan Birney
Serena Nik-Zainal
The topography of mutational processes in breast cancer genomes
description Mutational signatures provide evidence of the mechanism of action of a given mutagen and are found in cancer cells. Here, using 560 breast cancer genomes, the authors demonstrate that mutational signatures are frequently associated with genomic architecture including nucleosome positioning and replication timing.
format article
author Sandro Morganella
Ludmil B. Alexandrov
Dominik Glodzik
Xueqing Zou
Helen Davies
Johan Staaf
Anieta M. Sieuwerts
Arie B. Brinkman
Sancha Martin
Manasa Ramakrishna
Adam Butler
Hyung-Yong Kim
Åke Borg
Christos Sotiriou
P. Andrew Futreal
Peter J. Campbell
Paul N. Span
Steven Van Laere
Sunil R. Lakhani
Jorunn E. Eyfjord
Alastair M. Thompson
Hendrik G. Stunnenberg
Marc J. van de Vijver
John W. M. Martens
Anne-Lise Børresen-Dale
Andrea L. Richardson
Gu Kong
Gilles Thomas
Julian Sale
Cristina Rada
Michael R. Stratton
Ewan Birney
Serena Nik-Zainal
author_facet Sandro Morganella
Ludmil B. Alexandrov
Dominik Glodzik
Xueqing Zou
Helen Davies
Johan Staaf
Anieta M. Sieuwerts
Arie B. Brinkman
Sancha Martin
Manasa Ramakrishna
Adam Butler
Hyung-Yong Kim
Åke Borg
Christos Sotiriou
P. Andrew Futreal
Peter J. Campbell
Paul N. Span
Steven Van Laere
Sunil R. Lakhani
Jorunn E. Eyfjord
Alastair M. Thompson
Hendrik G. Stunnenberg
Marc J. van de Vijver
John W. M. Martens
Anne-Lise Børresen-Dale
Andrea L. Richardson
Gu Kong
Gilles Thomas
Julian Sale
Cristina Rada
Michael R. Stratton
Ewan Birney
Serena Nik-Zainal
author_sort Sandro Morganella
title The topography of mutational processes in breast cancer genomes
title_short The topography of mutational processes in breast cancer genomes
title_full The topography of mutational processes in breast cancer genomes
title_fullStr The topography of mutational processes in breast cancer genomes
title_full_unstemmed The topography of mutational processes in breast cancer genomes
title_sort topography of mutational processes in breast cancer genomes
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/03b87554fd0b4b03ab41b2913f616ad7
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