Analyses of a Ceftazidime-Avibactam-Resistant <italic toggle="yes">Citrobacter freundii</italic> Isolate Carrying <italic toggle="yes">bla</italic><sub>KPC-2</sub> Reveals a Heterogenous Population and Reversible Genotype

Analyses of a Ceftazidime-Avibactam-Resistant <italic toggle="yes">Citrobacter freundii</italic> Isolate Carrying <italic toggle="yes">bla</italic><sub>KPC-2</sub> Reveals a Heterogenous Population and Reversible Genotype

ABSTRACT A blaKPC-2-carrying Citrobacter freundii isolate developed ceftazidime-avibactam resistance during treatment with this agent. The initial and follow-up isolates exhibited ceftazidime-avibactam MICs of 4 and 64 µg/ml, respectively. Overexpression of AcrAB-TolC and porin alterations were dete...

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Autores principales: Mariana Castanheira, S. J. Ryan Arends, Andrew P. Davis, Leah N. Woosley, Amira A. Bhalodi, Shawn H. MacVane
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
Citrobacter freundii
β-lactams
ceftazidime-avibactam
resistance mechanism
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/03baac5888cf4fe3a5024e729a3b03a1
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