Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

In Gram-positive bacteria, lipoprotein intramolecular transacylase Lit produces a lipoprotein variant with less immunogenicity. As such, Lit can be viewed as a virulence factor. Here, structural and functional characterization of the enzyme provides insight into its catalytic mechanism, setting the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samir Olatunji, Katherine Bowen, Chia-Ying Huang, Dietmar Weichert, Warispreet Singh, Irina G. Tikhonova, Eoin M. Scanlan, Vincent Olieric, Martin Caffrey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03baf9b973b44bc2873d0ae3f2a3b65a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03baf9b973b44bc2873d0ae3f2a3b65a
record_format	dspace
spelling	oai:doaj.org-article:03baf9b973b44bc2873d0ae3f2a3b65a2021-12-02T17:01:14ZStructural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis10.1038/s41467-021-24475-02041-1723https://doaj.org/article/03baf9b973b44bc2873d0ae3f2a3b65a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24475-0https://doaj.org/toc/2041-1723In Gram-positive bacteria, lipoprotein intramolecular transacylase Lit produces a lipoprotein variant with less immunogenicity. As such, Lit can be viewed as a virulence factor. Here, structural and functional characterization of the enzyme provides insight into its catalytic mechanism, setting the stage for future studies of Lit as a target for new antibiotics.Samir OlatunjiKatherine BowenChia-Ying HuangDietmar WeichertWarispreet SinghIrina G. TikhonovaEoin M. ScanlanVincent OliericMartin CaffreyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samir Olatunji Katherine Bowen Chia-Ying Huang Dietmar Weichert Warispreet Singh Irina G. Tikhonova Eoin M. Scanlan Vincent Olieric Martin Caffrey Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
description	In Gram-positive bacteria, lipoprotein intramolecular transacylase Lit produces a lipoprotein variant with less immunogenicity. As such, Lit can be viewed as a virulence factor. Here, structural and functional characterization of the enzyme provides insight into its catalytic mechanism, setting the stage for future studies of Lit as a target for new antibiotics.
format	article
author	Samir Olatunji Katherine Bowen Chia-Ying Huang Dietmar Weichert Warispreet Singh Irina G. Tikhonova Eoin M. Scanlan Vincent Olieric Martin Caffrey
author_facet	Samir Olatunji Katherine Bowen Chia-Ying Huang Dietmar Weichert Warispreet Singh Irina G. Tikhonova Eoin M. Scanlan Vincent Olieric Martin Caffrey
author_sort	Samir Olatunji
title	Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
title_short	Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
title_full	Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
title_fullStr	Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
title_full_unstemmed	Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
title_sort	structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/03baf9b973b44bc2873d0ae3f2a3b65a
work_keys_str_mv	AT samirolatunji structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT katherinebowen structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT chiayinghuang structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT dietmarweichert structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT warispreetsingh structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT irinagtikhonova structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT eoinmscanlan structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT vincentolieric structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis AT martincaffrey structuralbasisofthemembraneintramoleculartransacylasereactionresponsibleforlysoformlipoproteinsynthesis
_version_	1718382190414266368

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

Ejemplares similares