Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
In Gram-positive bacteria, lipoprotein intramolecular transacylase Lit produces a lipoprotein variant with less immunogenicity. As such, Lit can be viewed as a virulence factor. Here, structural and functional characterization of the enzyme provides insight into its catalytic mechanism, setting the...
Guardado en:
Autores principales: | Samir Olatunji, Katherine Bowen, Chia-Ying Huang, Dietmar Weichert, Warispreet Singh, Irina G. Tikhonova, Eoin M. Scanlan, Vincent Olieric, Martin Caffrey |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/03baf9b973b44bc2873d0ae3f2a3b65a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
por: Samir Olatunji, et al.
Publicado: (2020) -
Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis
por: Maciej Wiktor, et al.
Publicado: (2017) -
Thermal selectivity of intermolecular versus intramolecular reactions on surfaces
por: Borja Cirera, et al.
Publicado: (2016) -
PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
por: Yusuke Ohno, et al.
Publicado: (2017) -
Enantioselective desymmetrization of cyclohexadienones via an intramolecular Rauhut–Currier reaction of allenoates
por: Weijun Yao, et al.
Publicado: (2016)