ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY

Objective: To conduct a morphological evaluation quantitatively of two types of tumor-infiltrating lymphocyte populations, including those located in the stroma and intraepithelial cancer structures, in patients with colorectal cancer. Study Design: Cross sectional study. Place and Duration of...

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Autores principales:	Amna Ameer, Farhan Akhtar, Hafeez Ud Din, Rabia Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	colorectal carcinoma intraepithelial cancer tumor infiltrating lymphocytes Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/03bb04947b924453a832f1f8ff731c66
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spelling	oai:doaj.org-article:03bb04947b924453a832f1f8ff731c662021-12-02T16:32:53ZASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY0030-96482411-884210.51253/pafmj.v71i2.4764https://doaj.org/article/03bb04947b924453a832f1f8ff731c662021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/4764https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To conduct a morphological evaluation quantitatively of two types of tumor-infiltrating lymphocyte populations, including those located in the stroma and intraepithelial cancer structures, in patients with colorectal cancer. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from Jan to Jul 2019. Methodology: Three levels of infiltration in the stroma by tumor infiltrating lymphocytes were determined. Level 1 was weak meaning (0-20% of stromal TILs), level 2 was moderate meaning (>20-50% of stromal TILs); and level 3 was strong meaning (50-90% of stromal TILs). TILs within tumor cells were divided into two groups. 0 meaning absent (no TILs present) and 1 meaning present (≥TILs in tumor cells) 1. Results: Out of 30 cases 22 were males and 8 females. Ages ranged between 25-83 with a mean of 57 years and a standard deviation of ± 16.4 years. All of the cases were diagnosed cases of adenocarcinoma. The levels of stromal tumor infiltrating lymphocytes was weak in 1 case, moderate in 18 cases and strong in 11 cases whereas intraepithelial lymphocytosis was seen in 22 cases. Conclusion: These results confirm that the infiltration of tumor infiltrating lymphocytes into the tumor in patients with colorectal carcinoma serves an important role in the invasion and progression of the disease, and should be considered in routine examinations.Amna AmeerFarhan AkhtarHafeez Ud DinRabia AhmedArmy Medical College Rawalpindiarticlecolorectal carcinomaintraepithelial cancertumor infiltrating lymphocytesMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 392-95 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal carcinoma intraepithelial cancer tumor infiltrating lymphocytes Medicine R Medicine (General) R5-920
spellingShingle	colorectal carcinoma intraepithelial cancer tumor infiltrating lymphocytes Medicine R Medicine (General) R5-920 Amna Ameer Farhan Akhtar Hafeez Ud Din Rabia Ahmed ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY
description	Objective: To conduct a morphological evaluation quantitatively of two types of tumor-infiltrating lymphocyte populations, including those located in the stroma and intraepithelial cancer structures, in patients with colorectal cancer. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from Jan to Jul 2019. Methodology: Three levels of infiltration in the stroma by tumor infiltrating lymphocytes were determined. Level 1 was weak meaning (0-20% of stromal TILs), level 2 was moderate meaning (>20-50% of stromal TILs); and level 3 was strong meaning (50-90% of stromal TILs). TILs within tumor cells were divided into two groups. 0 meaning absent (no TILs present) and 1 meaning present (≥TILs in tumor cells) 1. Results: Out of 30 cases 22 were males and 8 females. Ages ranged between 25-83 with a mean of 57 years and a standard deviation of ± 16.4 years. All of the cases were diagnosed cases of adenocarcinoma. The levels of stromal tumor infiltrating lymphocytes was weak in 1 case, moderate in 18 cases and strong in 11 cases whereas intraepithelial lymphocytosis was seen in 22 cases. Conclusion: These results confirm that the infiltration of tumor infiltrating lymphocytes into the tumor in patients with colorectal carcinoma serves an important role in the invasion and progression of the disease, and should be considered in routine examinations.
format	article
author	Amna Ameer Farhan Akhtar Hafeez Ud Din Rabia Ahmed
author_facet	Amna Ameer Farhan Akhtar Hafeez Ud Din Rabia Ahmed
author_sort	Amna Ameer
title	ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY
title_short	ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY
title_full	ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY
title_fullStr	ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY
title_full_unstemmed	ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY
title_sort	assessment of stromal and intra-epithelial tumor infiltrating lymphocytes in colorectal carcinoma at armed forces institute of pathology
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/03bb04947b924453a832f1f8ff731c66
work_keys_str_mv	AT amnaameer assessmentofstromalandintraepithelialtumorinfiltratinglymphocytesincolorectalcarcinomaatarmedforcesinstituteofpathology AT farhanakhtar assessmentofstromalandintraepithelialtumorinfiltratinglymphocytesincolorectalcarcinomaatarmedforcesinstituteofpathology AT hafeezuddin assessmentofstromalandintraepithelialtumorinfiltratinglymphocytesincolorectalcarcinomaatarmedforcesinstituteofpathology AT rabiaahmed assessmentofstromalandintraepithelialtumorinfiltratinglymphocytesincolorectalcarcinomaatarmedforcesinstituteofpathology
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ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY

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