A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate

The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert strictosidine to akuammicine, the stable shunt pro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Evangelos C. Tatsis, Inês Carqueijeiro, Thomas Dugé de Bernonville, Jakob Franke, Thu-Thuy T. Dang, Audrey Oudin, Arnaud Lanoue, Florent Lafontaine, Anna K. Stavrinides, Marc Clastre, Vincent Courdavault, Sarah E. O’Connor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03bb68418f55480082f388e21cdaf80b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03bb68418f55480082f388e21cdaf80b
record_format	dspace
spelling	oai:doaj.org-article:03bb68418f55480082f388e21cdaf80b2021-12-02T10:48:10ZA three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate10.1038/s41467-017-00154-x2041-1723https://doaj.org/article/03bb68418f55480082f388e21cdaf80b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00154-xhttps://doaj.org/toc/2041-1723The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert strictosidine to akuammicine, the stable shunt product of preakuammicine.Evangelos C. TatsisInês CarqueijeiroThomas Dugé de BernonvilleJakob FrankeThu-Thuy T. DangAudrey OudinArnaud LanoueFlorent LafontaineAnna K. StavrinidesMarc ClastreVincent CourdavaultSarah E. O’ConnorNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evangelos C. Tatsis Inês Carqueijeiro Thomas Dugé de Bernonville Jakob Franke Thu-Thuy T. Dang Audrey Oudin Arnaud Lanoue Florent Lafontaine Anna K. Stavrinides Marc Clastre Vincent Courdavault Sarah E. O’Connor A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
description	The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert strictosidine to akuammicine, the stable shunt product of preakuammicine.
format	article
author	Evangelos C. Tatsis Inês Carqueijeiro Thomas Dugé de Bernonville Jakob Franke Thu-Thuy T. Dang Audrey Oudin Arnaud Lanoue Florent Lafontaine Anna K. Stavrinides Marc Clastre Vincent Courdavault Sarah E. O’Connor
author_facet	Evangelos C. Tatsis Inês Carqueijeiro Thomas Dugé de Bernonville Jakob Franke Thu-Thuy T. Dang Audrey Oudin Arnaud Lanoue Florent Lafontaine Anna K. Stavrinides Marc Clastre Vincent Courdavault Sarah E. O’Connor
author_sort	Evangelos C. Tatsis
title	A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
title_short	A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
title_full	A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
title_fullStr	A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
title_full_unstemmed	A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate
title_sort	three enzyme system to generate the strychnos alkaloid scaffold from a central biosynthetic intermediate
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/03bb68418f55480082f388e21cdaf80b
work_keys_str_mv	AT evangelosctatsis athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT inescarqueijeiro athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT thomasdugedebernonville athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT jakobfranke athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT thuthuytdang athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT audreyoudin athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT arnaudlanoue athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT florentlafontaine athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT annakstavrinides athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT marcclastre athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT vincentcourdavault athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT saraheoconnor athreeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT evangelosctatsis threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT inescarqueijeiro threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT thomasdugedebernonville threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT jakobfranke threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT thuthuytdang threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT audreyoudin threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT arnaudlanoue threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT florentlafontaine threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT annakstavrinides threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT marcclastre threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT vincentcourdavault threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate AT saraheoconnor threeenzymesystemtogeneratethestrychnosalkaloidscaffoldfromacentralbiosyntheticintermediate
_version_	1718396628345290752

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate

Ejemplares similares