Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate the role of PRMT7 in the cellular stress response.

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Autores principales:	Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03bef969e65b4b6bb250bb2886960e81
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spelling	oai:doaj.org-article:03bef969e65b4b6bb250bb2886960e812021-12-02T17:16:10ZPharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response10.1038/s41467-020-16271-z2041-1723https://doaj.org/article/03bef969e65b4b6bb250bb2886960e812020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16271-zhttps://doaj.org/toc/2041-1723Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate the role of PRMT7 in the cellular stress response.Magdalena M. SzewczykYoshinori IshikawaShawna OrganNozomu SakaiFengling LiLevon HalabelianSuzanne AcklooAmber L. CouzensMohammad EramDavid DilworthHideto FukushiRachel HardingCarlo C. dela SeñaTsukasa SugoKozo HayashiDavid McLeodCarlos ZepedaAhmed AmanMaria Sánchez-OsunaEric BonneilShinji TakagiRima Al-AwarMike TyersStephane RichardMasayuki TakizawaAnne-Claude GingrasCheryl H. ArrowsmithMasoud VedadiPeter J. BrownHiroshi NaraDalia Barsyte-LovejoyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Magdalena M. Szewczyk Yoshinori Ishikawa Shawna Organ Nozomu Sakai Fengling Li Levon Halabelian Suzanne Ackloo Amber L. Couzens Mohammad Eram David Dilworth Hideto Fukushi Rachel Harding Carlo C. dela Seña Tsukasa Sugo Kozo Hayashi David McLeod Carlos Zepeda Ahmed Aman Maria Sánchez-Osuna Eric Bonneil Shinji Takagi Rima Al-Awar Mike Tyers Stephane Richard Masayuki Takizawa Anne-Claude Gingras Cheryl H. Arrowsmith Masoud Vedadi Peter J. Brown Hiroshi Nara Dalia Barsyte-Lovejoy Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
description	Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate the role of PRMT7 in the cellular stress response.
format	article
author	Magdalena M. Szewczyk Yoshinori Ishikawa Shawna Organ Nozomu Sakai Fengling Li Levon Halabelian Suzanne Ackloo Amber L. Couzens Mohammad Eram David Dilworth Hideto Fukushi Rachel Harding Carlo C. dela Seña Tsukasa Sugo Kozo Hayashi David McLeod Carlos Zepeda Ahmed Aman Maria Sánchez-Osuna Eric Bonneil Shinji Takagi Rima Al-Awar Mike Tyers Stephane Richard Masayuki Takizawa Anne-Claude Gingras Cheryl H. Arrowsmith Masoud Vedadi Peter J. Brown Hiroshi Nara Dalia Barsyte-Lovejoy
author_facet	Magdalena M. Szewczyk Yoshinori Ishikawa Shawna Organ Nozomu Sakai Fengling Li Levon Halabelian Suzanne Ackloo Amber L. Couzens Mohammad Eram David Dilworth Hideto Fukushi Rachel Harding Carlo C. dela Seña Tsukasa Sugo Kozo Hayashi David McLeod Carlos Zepeda Ahmed Aman Maria Sánchez-Osuna Eric Bonneil Shinji Takagi Rima Al-Awar Mike Tyers Stephane Richard Masayuki Takizawa Anne-Claude Gingras Cheryl H. Arrowsmith Masoud Vedadi Peter J. Brown Hiroshi Nara Dalia Barsyte-Lovejoy
author_sort	Magdalena M. Szewczyk
title	Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
title_short	Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
title_full	Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
title_fullStr	Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
title_full_unstemmed	Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
title_sort	pharmacological inhibition of prmt7 links arginine monomethylation to the cellular stress response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/03bef969e65b4b6bb250bb2886960e81
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Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

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