Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography

Abstract To determine the risk factors and unique characteristics of keratoconus (KC) progression after penetrating keratoplasty (PK), anterior segment optical coherence tomography parameters were statistically analyzed in comparison with eyes undergoing PK for other diseases as a control. Ninety-on...

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Autores principales:	Junko Yoshida, Tetsuya Toyono, Rika Shirakawa, Takashi Miyai, Tomohiko Usui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03c325e8895f4abeaec09ac1c4a463b0
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spelling	oai:doaj.org-article:03c325e8895f4abeaec09ac1c4a463b02021-12-02T15:10:24ZRisk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography10.1038/s41598-020-75412-y2045-2322https://doaj.org/article/03c325e8895f4abeaec09ac1c4a463b02020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-75412-yhttps://doaj.org/toc/2045-2322Abstract To determine the risk factors and unique characteristics of keratoconus (KC) progression after penetrating keratoplasty (PK), anterior segment optical coherence tomography parameters were statistically analyzed in comparison with eyes undergoing PK for other diseases as a control. Ninety-one eyes maintaining clear PK grafts for over 10 years were divided into 2 groups according to the primary indication for PK (KC vs Others groups). Corneal thinning indicators (inferior host thinnest corneal thickness/central corneal thickness [IHT/CCT], inferior graft thinnest corneal thickness/CCT [IGT/CCT]), were smaller whereas anterior chamber depth, and steepest corneal power (Ks), and maximum corneal power (Kmax) were larger in the KC group with statistical significance. Graft size, Kmax and Ks correlated with IHT/CCT and IGT/CCT in the KC group. These correlations were not detected in controls. Graft size and postoperative period were selected by multivariate regression analysis as factors for corneal ectatic changes in the KC group. In conclusion, KC eyes long after PK show inferior graft and host corneal thinning, and corneal protrusion. Corneal power parameters such as Kmax or Ks can be used to monitor KC progression after PK. A small graft might lead to KC progression after PK.Junko YoshidaTetsuya ToyonoRika ShirakawaTakashi MiyaiTomohiko UsuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junko Yoshida Tetsuya Toyono Rika Shirakawa Takashi Miyai Tomohiko Usui Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography
description	Abstract To determine the risk factors and unique characteristics of keratoconus (KC) progression after penetrating keratoplasty (PK), anterior segment optical coherence tomography parameters were statistically analyzed in comparison with eyes undergoing PK for other diseases as a control. Ninety-one eyes maintaining clear PK grafts for over 10 years were divided into 2 groups according to the primary indication for PK (KC vs Others groups). Corneal thinning indicators (inferior host thinnest corneal thickness/central corneal thickness [IHT/CCT], inferior graft thinnest corneal thickness/CCT [IGT/CCT]), were smaller whereas anterior chamber depth, and steepest corneal power (Ks), and maximum corneal power (Kmax) were larger in the KC group with statistical significance. Graft size, Kmax and Ks correlated with IHT/CCT and IGT/CCT in the KC group. These correlations were not detected in controls. Graft size and postoperative period were selected by multivariate regression analysis as factors for corneal ectatic changes in the KC group. In conclusion, KC eyes long after PK show inferior graft and host corneal thinning, and corneal protrusion. Corneal power parameters such as Kmax or Ks can be used to monitor KC progression after PK. A small graft might lead to KC progression after PK.
format	article
author	Junko Yoshida Tetsuya Toyono Rika Shirakawa Takashi Miyai Tomohiko Usui
author_facet	Junko Yoshida Tetsuya Toyono Rika Shirakawa Takashi Miyai Tomohiko Usui
author_sort	Junko Yoshida
title	Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography
title_short	Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography
title_full	Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography
title_fullStr	Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography
title_full_unstemmed	Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography
title_sort	risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/03c325e8895f4abeaec09ac1c4a463b0
work_keys_str_mv	AT junkoyoshida riskfactorsandevaluationofkeratoconusprogressionafterpenetratingkeratoplastywithanteriorsegmentopticalcoherencetomography AT tetsuyatoyono riskfactorsandevaluationofkeratoconusprogressionafterpenetratingkeratoplastywithanteriorsegmentopticalcoherencetomography AT rikashirakawa riskfactorsandevaluationofkeratoconusprogressionafterpenetratingkeratoplastywithanteriorsegmentopticalcoherencetomography AT takashimiyai riskfactorsandevaluationofkeratoconusprogressionafterpenetratingkeratoplastywithanteriorsegmentopticalcoherencetomography AT tomohikousui riskfactorsandevaluationofkeratoconusprogressionafterpenetratingkeratoplastywithanteriorsegmentopticalcoherencetomography
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Risk factors and evaluation of keratoconus progression after penetrating keratoplasty with anterior segment optical coherence tomography

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