A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma
Genes that modulate the cytoskeleton have been associated with increased cell proliferation and migration. Here, the authors show that AVIL, an actin regulatory protein, is overexpressed in glioblastomas and mediates oncogenic effects through regulation of FOXM1 stability and LIN28B expression.
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| Lenguaje: | EN |
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/03c59fd5f35148edbce45f1cfce5d926 |
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oai:doaj.org-article:03c59fd5f35148edbce45f1cfce5d9262021-12-02T18:34:08ZA cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma10.1038/s41467-020-17279-12041-1723https://doaj.org/article/03c59fd5f35148edbce45f1cfce5d9262020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17279-1https://doaj.org/toc/2041-1723Genes that modulate the cytoskeleton have been associated with increased cell proliferation and migration. Here, the authors show that AVIL, an actin regulatory protein, is overexpressed in glioblastomas and mediates oncogenic effects through regulation of FOXM1 stability and LIN28B expression.Zhongqiu XiePawel Ł. JanczykYing ZhangAiqun LiuXinrui ShiSandeep SinghLoryn FacemireKristopher KubowZi LiYuemeng JiaDorothy SchaferJames W. MandellRoger AbounaderHui LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zhongqiu Xie Pawel Ł. Janczyk Ying Zhang Aiqun Liu Xinrui Shi Sandeep Singh Loryn Facemire Kristopher Kubow Zi Li Yuemeng Jia Dorothy Schafer James W. Mandell Roger Abounader Hui Li A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma |
| description |
Genes that modulate the cytoskeleton have been associated with increased cell proliferation and migration. Here, the authors show that AVIL, an actin regulatory protein, is overexpressed in glioblastomas and mediates oncogenic effects through regulation of FOXM1 stability and LIN28B expression. |
| format |
article |
| author |
Zhongqiu Xie Pawel Ł. Janczyk Ying Zhang Aiqun Liu Xinrui Shi Sandeep Singh Loryn Facemire Kristopher Kubow Zi Li Yuemeng Jia Dorothy Schafer James W. Mandell Roger Abounader Hui Li |
| author_facet |
Zhongqiu Xie Pawel Ł. Janczyk Ying Zhang Aiqun Liu Xinrui Shi Sandeep Singh Loryn Facemire Kristopher Kubow Zi Li Yuemeng Jia Dorothy Schafer James W. Mandell Roger Abounader Hui Li |
| author_sort |
Zhongqiu Xie |
| title |
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma |
| title_short |
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma |
| title_full |
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma |
| title_fullStr |
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma |
| title_full_unstemmed |
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma |
| title_sort |
cytoskeleton regulator avil drives tumorigenesis in glioblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/03c59fd5f35148edbce45f1cfce5d926 |
| work_keys_str_mv |
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1718377900006178816 |