Clinical features and related factors of freezing of gait in patients with Parkinson's disease

Abstract Background Freezing of gait (FOG) is a disabling paroxysmal gait disorder that prevents starting or resuming walking, which seriously negatively affects patients’ quality of life (QOL). The diagnosis and treatment of FOG remain a huge medical challenge. The purpose of this study was to expl...

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Autores principales:	Fengting Zhang, Jin Shi, Yangyang Duan, Jiang Cheng, Hui Li, Tingting Xuan, Yue Lv, Peng Wang, Haining Li
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	freezing of gait new gait freezing questionnaire Parkinson's disease related factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/03c7b7f16e734164a1ab3e23db68a2c6
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spelling	oai:doaj.org-article:03c7b7f16e734164a1ab3e23db68a2c62021-11-25T06:06:36ZClinical features and related factors of freezing of gait in patients with Parkinson's disease2162-327910.1002/brb3.2359https://doaj.org/article/03c7b7f16e734164a1ab3e23db68a2c62021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2359https://doaj.org/toc/2162-3279Abstract Background Freezing of gait (FOG) is a disabling paroxysmal gait disorder that prevents starting or resuming walking, which seriously negatively affects patients’ quality of life (QOL). The diagnosis and treatment of FOG remain a huge medical challenge. The purpose of this study was to explore the clinical characteristics and related factors of FOG in patients with Parkinson's disease (PD). Methods The motor and nonmotor symptoms of a total number of 77 PD patients were evaluated. Patients with or without FOG were defined as a score ≥1 in the new freezing of gait questionnaire (NFOG‐Q). A comparative study between patients with and without FOG was conducted. Results In this investigation, the prevalence of FOG was 48%. The patients with FOG had longer disease duration, higher Hoehn‐Yahr stage (H‐Y stage), higher dose of dopaminergic agents, and higher nonmotor and motor symptom scores. A significant positive correlation was found between the NFOG‐Q score and the H‐Y stage, PIGD subscore, PDQ‐39, and the attention/memory in the nonmotor symptoms assessment scale (NMSS) subitem (r > 0.5, p < .05). The binary logistic regression analysis showed that the higher H‐Y stage, higher rigidity subscore and Unified Parkinson's Disease Rating Scale II (UPDRS II) score, and UPDRS III score were significantly correlated with the occurrence of FOG (p < .05). In the analysis of the frequency of FOG, the prevalence of FOG in H‐Y stage was higher in the middle and late stages, and the prevalence of FOG increased with the increase in PDQ‐39 scores. Conclusion The severity of FOG was significantly positively correlated with the H‐Y stage, PIGD subscore, PDQ‐39 score, and attention/memory score. Based on our findings, we conclude that the clinical characteristics of rigidity can be used as a potential predictor of FOG.Fengting ZhangJin ShiYangyang DuanJiang ChengHui LiTingting XuanYue LvPeng WangHaining LiWileyarticlefreezing of gaitnew gait freezing questionnaireParkinson's diseaserelated factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	freezing of gait new gait freezing questionnaire Parkinson's disease related factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	freezing of gait new gait freezing questionnaire Parkinson's disease related factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Fengting Zhang Jin Shi Yangyang Duan Jiang Cheng Hui Li Tingting Xuan Yue Lv Peng Wang Haining Li Clinical features and related factors of freezing of gait in patients with Parkinson's disease
description	Abstract Background Freezing of gait (FOG) is a disabling paroxysmal gait disorder that prevents starting or resuming walking, which seriously negatively affects patients’ quality of life (QOL). The diagnosis and treatment of FOG remain a huge medical challenge. The purpose of this study was to explore the clinical characteristics and related factors of FOG in patients with Parkinson's disease (PD). Methods The motor and nonmotor symptoms of a total number of 77 PD patients were evaluated. Patients with or without FOG were defined as a score ≥1 in the new freezing of gait questionnaire (NFOG‐Q). A comparative study between patients with and without FOG was conducted. Results In this investigation, the prevalence of FOG was 48%. The patients with FOG had longer disease duration, higher Hoehn‐Yahr stage (H‐Y stage), higher dose of dopaminergic agents, and higher nonmotor and motor symptom scores. A significant positive correlation was found between the NFOG‐Q score and the H‐Y stage, PIGD subscore, PDQ‐39, and the attention/memory in the nonmotor symptoms assessment scale (NMSS) subitem (r > 0.5, p < .05). The binary logistic regression analysis showed that the higher H‐Y stage, higher rigidity subscore and Unified Parkinson's Disease Rating Scale II (UPDRS II) score, and UPDRS III score were significantly correlated with the occurrence of FOG (p < .05). In the analysis of the frequency of FOG, the prevalence of FOG in H‐Y stage was higher in the middle and late stages, and the prevalence of FOG increased with the increase in PDQ‐39 scores. Conclusion The severity of FOG was significantly positively correlated with the H‐Y stage, PIGD subscore, PDQ‐39 score, and attention/memory score. Based on our findings, we conclude that the clinical characteristics of rigidity can be used as a potential predictor of FOG.
format	article
author	Fengting Zhang Jin Shi Yangyang Duan Jiang Cheng Hui Li Tingting Xuan Yue Lv Peng Wang Haining Li
author_facet	Fengting Zhang Jin Shi Yangyang Duan Jiang Cheng Hui Li Tingting Xuan Yue Lv Peng Wang Haining Li
author_sort	Fengting Zhang
title	Clinical features and related factors of freezing of gait in patients with Parkinson's disease
title_short	Clinical features and related factors of freezing of gait in patients with Parkinson's disease
title_full	Clinical features and related factors of freezing of gait in patients with Parkinson's disease
title_fullStr	Clinical features and related factors of freezing of gait in patients with Parkinson's disease
title_full_unstemmed	Clinical features and related factors of freezing of gait in patients with Parkinson's disease
title_sort	clinical features and related factors of freezing of gait in patients with parkinson's disease
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/03c7b7f16e734164a1ab3e23db68a2c6
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_version_	1718414144292519936

Clinical features and related factors of freezing of gait in patients with Parkinson's disease

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