Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

Rafał Filip,1,2 Radosław P Radzki,3 Marek Bieńko3 1Department of Gastroenterology with IBD Unit, Clinical Hospital 2, Rzeszów, Poland; 2University of Rzeszów, Rzeszów, Poland; 3Department of Animal Physiology, University of Life Sciences, Lublin, Poland Abstract: E...

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Autores principales:	Filip R, Radzki RP, Bieńko M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nonalcoholic fatty liver disease nonalcoholic steatohepatitis inflammation osteoporosis bone metabolism Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/03ca04bfa93a40418c16389bdd31f74d
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spelling	oai:doaj.org-article:03ca04bfa93a40418c16389bdd31f74d2021-12-02T07:52:55ZNovel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis1178-1998https://doaj.org/article/03ca04bfa93a40418c16389bdd31f74d2018-10-01T00:00:00Zhttps://www.dovepress.com/novel-insights-into-the-relationship-between-nonalcoholic-fatty-liver--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rafał Filip,1,2 Radosław P Radzki,3 Marek Bieńko3 1Department of Gastroenterology with IBD Unit, Clinical Hospital 2, Rzeszów, Poland; 2University of Rzeszów, Rzeszów, Poland; 3Department of Animal Physiology, University of Life Sciences, Lublin, Poland Abstract: Excess fat deposition and insulin resistance are considered the main risk factors for nonalcoholic fatty liver disease (NAFLD), and therefore, not surprisingly, the global prevalence of NAFLD increases in parallel with both obesity and type 2 diabetes. Although deterioration of bone homeostasis in patients with NAFLD is commonly observed, its etiology has not been fully elucidated yet. It was shown in several studies that bone tissue seems to be independently associated with NAFLD. A mechanistic perspective puts the liver at the center of mutual interdependencies obviously involving adipose tissue and muscles and also the bone matrix and bone cells, which are relatively novel. In this review, various pathophysiological mechanisms and possible mediating molecules that may interplay between NAFLD and bone tissue are described. Chronic inflammation, vitamin D3, growth hormone, insulin-like growth factor 1, osteopontin, fetuin-A, irisin, osteocalcin, and osteoprotegerin from osteoblasts have been proposed as mediators of mutual interactions among the skeleton, fatty tissue, and liver. Although to date there are still many issues that have not been elucidated, growing evidence suggests that screening and surveillance of bone mineral density in patients with NAFLD should be considered in future strategies and guidelines for NAFLD management. Keywords: nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, inflammation, osteoporosis, bone metabolismFilip RRadzki RPBieńko MDove Medical Pressarticlenonalcoholic fatty liver diseasenonalcoholic steatohepatitisinflammationosteoporosisbone metabolismGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1879-1891 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nonalcoholic fatty liver disease nonalcoholic steatohepatitis inflammation osteoporosis bone metabolism Geriatrics RC952-954.6
spellingShingle	nonalcoholic fatty liver disease nonalcoholic steatohepatitis inflammation osteoporosis bone metabolism Geriatrics RC952-954.6 Filip R Radzki RP Bieńko M Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
description	Rafał Filip,1,2 Radosław P Radzki,3 Marek Bieńko3 1Department of Gastroenterology with IBD Unit, Clinical Hospital 2, Rzeszów, Poland; 2University of Rzeszów, Rzeszów, Poland; 3Department of Animal Physiology, University of Life Sciences, Lublin, Poland Abstract: Excess fat deposition and insulin resistance are considered the main risk factors for nonalcoholic fatty liver disease (NAFLD), and therefore, not surprisingly, the global prevalence of NAFLD increases in parallel with both obesity and type 2 diabetes. Although deterioration of bone homeostasis in patients with NAFLD is commonly observed, its etiology has not been fully elucidated yet. It was shown in several studies that bone tissue seems to be independently associated with NAFLD. A mechanistic perspective puts the liver at the center of mutual interdependencies obviously involving adipose tissue and muscles and also the bone matrix and bone cells, which are relatively novel. In this review, various pathophysiological mechanisms and possible mediating molecules that may interplay between NAFLD and bone tissue are described. Chronic inflammation, vitamin D3, growth hormone, insulin-like growth factor 1, osteopontin, fetuin-A, irisin, osteocalcin, and osteoprotegerin from osteoblasts have been proposed as mediators of mutual interactions among the skeleton, fatty tissue, and liver. Although to date there are still many issues that have not been elucidated, growing evidence suggests that screening and surveillance of bone mineral density in patients with NAFLD should be considered in future strategies and guidelines for NAFLD management. Keywords: nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, inflammation, osteoporosis, bone metabolism
format	article
author	Filip R Radzki RP Bieńko M
author_facet	Filip R Radzki RP Bieńko M
author_sort	Filip R
title	Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
title_short	Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
title_full	Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
title_fullStr	Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
title_full_unstemmed	Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
title_sort	novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/03ca04bfa93a40418c16389bdd31f74d
work_keys_str_mv	AT filipr novelinsightsintotherelationshipbetweennonalcoholicfattyliverdiseaseandosteoporosis AT radzkirp novelinsightsintotherelationshipbetweennonalcoholicfattyliverdiseaseandosteoporosis AT bienkom novelinsightsintotherelationshipbetweennonalcoholicfattyliverdiseaseandosteoporosis
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Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

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