Merkel cell polyomavirus T-antigens regulate DICER1 mRNA stability and translation through HSC70
Summary: Merkel cell carcinoma is an aggressive skin malignancy, mostly caused by Merkel cell polyomavirus (MCPyV). MCPyV T-antigens can induce mature microRNA expressions through the DnaJ domain, but its underlying mechanism is still unknown. Here, we report that the T-antigens induce protein expre...
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Auteurs principaux: | Jiwei Gao, Hao Shi, C Christofer Juhlin, Catharina Larsson, Weng-Onn Lui |
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Format: | article |
Langue: | EN |
Publié: |
Elsevier
2021
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Accès en ligne: | https://doaj.org/article/03d4e6fb2f8345aab5a103e9a9fed38e |
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