Cardiac tissue engineering and regeneration using cell-based therapy

Mohammad T Alrefai,1–3 Divya Murali,4 Arghya Paul,4 Khalid M Ridwan,1,2 John M Connell,1,2 Dominique Shum-Tim1,2 1Division of Cardiac Surgery, 2Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada; 3King Faisal Specialist Hospital and Research Center, Jeddah...

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Autores principales:	Alrefai MT, Murali D, Paul A, Ridwan KM, Connell JM, Shum-Tim D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/03da0e4d41e64bdf912af6f528a402d4
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spelling	oai:doaj.org-article:03da0e4d41e64bdf912af6f528a402d42021-12-02T07:31:51ZCardiac tissue engineering and regeneration using cell-based therapy1178-6957https://doaj.org/article/03da0e4d41e64bdf912af6f528a402d42015-05-01T00:00:00Zhttp://www.dovepress.com/cardiac-tissue-engineering-and-regeneration-using-cell-based-therapy-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Mohammad T Alrefai,1–3 Divya Murali,4 Arghya Paul,4 Khalid M Ridwan,1,2 John M Connell,1,2 Dominique Shum-Tim1,2 1Division of Cardiac Surgery, 2Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada; 3King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; 4Department of Chemical and Petroleum Engineering, School of Engineering, University of Kansas, Lawrence, KS, USA Abstract: Stem cell therapy and tissue engineering represent a forefront of current research in the treatment of heart disease. With these technologies, advancements are being made into therapies for acute ischemic myocardial injury and chronic, otherwise nonreversible, myocardial failure. The current clinical management of cardiac ischemia deals with reestablishing perfusion to the heart but not dealing with the irreversible damage caused by the occlusion or stenosis of the supplying vessels. The applications of these new technologies are not yet fully established as part of the management of cardiac diseases but will become so in the near future. The discussion presented here reviews some of the pioneering works at this new frontier. Key results of allogeneic and autologous stem cell trials are presented, including the use of embryonic, bone marrow-derived, adipose-derived, and resident cardiac stem cells. Keywords: stem cells, cardiomyocytes, cardiac surgery, heart failure, myocardial ischemia, heart, scaffolds, organoids, cell sheet and tissue engineeringAlrefai MTMurali DPaul ARidwan KMConnell JMShum-Tim DDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 81-101 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Alrefai MT Murali D Paul A Ridwan KM Connell JM Shum-Tim D Cardiac tissue engineering and regeneration using cell-based therapy
description	Mohammad T Alrefai,1–3 Divya Murali,4 Arghya Paul,4 Khalid M Ridwan,1,2 John M Connell,1,2 Dominique Shum-Tim1,2 1Division of Cardiac Surgery, 2Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada; 3King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; 4Department of Chemical and Petroleum Engineering, School of Engineering, University of Kansas, Lawrence, KS, USA Abstract: Stem cell therapy and tissue engineering represent a forefront of current research in the treatment of heart disease. With these technologies, advancements are being made into therapies for acute ischemic myocardial injury and chronic, otherwise nonreversible, myocardial failure. The current clinical management of cardiac ischemia deals with reestablishing perfusion to the heart but not dealing with the irreversible damage caused by the occlusion or stenosis of the supplying vessels. The applications of these new technologies are not yet fully established as part of the management of cardiac diseases but will become so in the near future. The discussion presented here reviews some of the pioneering works at this new frontier. Key results of allogeneic and autologous stem cell trials are presented, including the use of embryonic, bone marrow-derived, adipose-derived, and resident cardiac stem cells. Keywords: stem cells, cardiomyocytes, cardiac surgery, heart failure, myocardial ischemia, heart, scaffolds, organoids, cell sheet and tissue engineering
format	article
author	Alrefai MT Murali D Paul A Ridwan KM Connell JM Shum-Tim D
author_facet	Alrefai MT Murali D Paul A Ridwan KM Connell JM Shum-Tim D
author_sort	Alrefai MT
title	Cardiac tissue engineering and regeneration using cell-based therapy
title_short	Cardiac tissue engineering and regeneration using cell-based therapy
title_full	Cardiac tissue engineering and regeneration using cell-based therapy
title_fullStr	Cardiac tissue engineering and regeneration using cell-based therapy
title_full_unstemmed	Cardiac tissue engineering and regeneration using cell-based therapy
title_sort	cardiac tissue engineering and regeneration using cell-based therapy
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/03da0e4d41e64bdf912af6f528a402d4
work_keys_str_mv	AT alrefaimt cardiactissueengineeringandregenerationusingcellbasedtherapy AT muralid cardiactissueengineeringandregenerationusingcellbasedtherapy AT paula cardiactissueengineeringandregenerationusingcellbasedtherapy AT ridwankm cardiactissueengineeringandregenerationusingcellbasedtherapy AT connelljm cardiactissueengineeringandregenerationusingcellbasedtherapy AT shumtimd cardiactissueengineeringandregenerationusingcellbasedtherapy
_version_	1718399380518600704

Cardiac tissue engineering and regeneration using cell-based therapy

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