Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease

Abstract Monocytes are important mediators of immune system and are reported to be altered in autoimmune disorders. Little is known about the pathological role of monocytes in Graves’ disease (GD). Thus, we investigated monocytes in periphery and thyroid tissue in GD. Untreated GD patients were enro...

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Autores principales:	Xinxin Chen, Yanqiu Wang, Yicheng Qi, Jiqi Yan, Fengjiao Huang, Mengxi Zhou, Weiqing Wang, Guang Ning, Yulin Zhou, Shu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03dbbff8e5d2455eb238a6b964738a12
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spelling	oai:doaj.org-article:03dbbff8e5d2455eb238a6b964738a122021-12-02T16:32:13ZExpansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease10.1038/s41598-021-92737-42045-2322https://doaj.org/article/03dbbff8e5d2455eb238a6b964738a122021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92737-4https://doaj.org/toc/2045-2322Abstract Monocytes are important mediators of immune system and are reported to be altered in autoimmune disorders. Little is known about the pathological role of monocytes in Graves’ disease (GD). Thus, we investigated monocytes in periphery and thyroid tissue in GD. Untreated GD patients were enrolled and followed up until remission. Monocytes were significantly increased and positively correlated with anti-thyrotropin receptor antibody (TRAb) in untreated GD (r counts = 0.269, P < 0.001; r percentage = 0.338, P < 0.001). Flow cytometry showed CD14++ CD16+ monocytes were increased and CD14++ CD16- monocytes were decreased in untreated GD (both P < 0.001). Skewed monocyte subsets were recovered in GD with remission. Serum B cell-activating factor (BAFF) was positively correlated with TRAb (r = 0.384 and P = 0.001). CD14++ CD16+ monocytes expressed higher level of BAFF in untreated GD (P < 0.05). The frequency of CD14+ monocytes and CD14+ CD16+ monocytes were significantly higher in GD thyroid tissue than in normal thyroid tissue (both P < 0.001). Our study suggested CD14++ CD16+ monocytes were significantly expanded and involved in the production of TRAb via secreting a higher level of BAFF in periphery. Besides, monocytes infiltrated into thyroid tissue and thus could serve as an important participant in GD pathogenesis.Xinxin ChenYanqiu WangYicheng QiJiqi YanFengjiao HuangMengxi ZhouWeiqing WangGuang NingYulin ZhouShu WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xinxin Chen Yanqiu Wang Yicheng Qi Jiqi Yan Fengjiao Huang Mengxi Zhou Weiqing Wang Guang Ning Yulin Zhou Shu Wang Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease
description	Abstract Monocytes are important mediators of immune system and are reported to be altered in autoimmune disorders. Little is known about the pathological role of monocytes in Graves’ disease (GD). Thus, we investigated monocytes in periphery and thyroid tissue in GD. Untreated GD patients were enrolled and followed up until remission. Monocytes were significantly increased and positively correlated with anti-thyrotropin receptor antibody (TRAb) in untreated GD (r counts = 0.269, P < 0.001; r percentage = 0.338, P < 0.001). Flow cytometry showed CD14++ CD16+ monocytes were increased and CD14++ CD16- monocytes were decreased in untreated GD (both P < 0.001). Skewed monocyte subsets were recovered in GD with remission. Serum B cell-activating factor (BAFF) was positively correlated with TRAb (r = 0.384 and P = 0.001). CD14++ CD16+ monocytes expressed higher level of BAFF in untreated GD (P < 0.05). The frequency of CD14+ monocytes and CD14+ CD16+ monocytes were significantly higher in GD thyroid tissue than in normal thyroid tissue (both P < 0.001). Our study suggested CD14++ CD16+ monocytes were significantly expanded and involved in the production of TRAb via secreting a higher level of BAFF in periphery. Besides, monocytes infiltrated into thyroid tissue and thus could serve as an important participant in GD pathogenesis.
format	article
author	Xinxin Chen Yanqiu Wang Yicheng Qi Jiqi Yan Fengjiao Huang Mengxi Zhou Weiqing Wang Guang Ning Yulin Zhou Shu Wang
author_facet	Xinxin Chen Yanqiu Wang Yicheng Qi Jiqi Yan Fengjiao Huang Mengxi Zhou Weiqing Wang Guang Ning Yulin Zhou Shu Wang
author_sort	Xinxin Chen
title	Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease
title_short	Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease
title_full	Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease
title_fullStr	Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease
title_full_unstemmed	Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease
title_sort	expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in graves’ disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/03dbbff8e5d2455eb238a6b964738a12
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Expansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease

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