The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16

The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16

Phosphatidylinositol 3-kinase catalyzes the reaction from PI(4,5)P2 to PI(3,4,5)P3 and is encoded by the age-1 gene known to regulate lifespan. Here the researchers found that the metabolite myo-inositol, which can be converted to PI(3,4,5)P3 extends worm lifespan and alleviates worm as well as mous...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dawei Shi, Xian Xia, Aoyuan Cui, Zhongxiang Xiong, Yizhen Yan, Jing Luo, Guoyu Chen, Yingying Zeng, Donghong Cai, Lei Hou, Joseph McDermott, Yu Li, Hong Zhang, Jing-Dong J. Han
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/03dcd5894eac4984b395ddc104128303
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:03dcd5894eac4984b395ddc104128303
record_format dspace
spelling oai:doaj.org-article:03dcd5894eac4984b395ddc1041283032021-12-02T18:03:07ZThe precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-1610.1038/s41467-020-18280-42041-1723https://doaj.org/article/03dcd5894eac4984b395ddc1041283032020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18280-4https://doaj.org/toc/2041-1723Phosphatidylinositol 3-kinase catalyzes the reaction from PI(4,5)P2 to PI(3,4,5)P3 and is encoded by the age-1 gene known to regulate lifespan. Here the researchers found that the metabolite myo-inositol, which can be converted to PI(3,4,5)P3 extends worm lifespan and alleviates worm as well as mouse health decline during aging.Dawei ShiXian XiaAoyuan CuiZhongxiang XiongYizhen YanJing LuoGuoyu ChenYingying ZengDonghong CaiLei HouJoseph McDermottYu LiHong ZhangJing-Dong J. HanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dawei Shi
Xian Xia
Aoyuan Cui
Zhongxiang Xiong
Yizhen Yan
Jing Luo
Guoyu Chen
Yingying Zeng
Donghong Cai
Lei Hou
Joseph McDermott
Yu Li
Hong Zhang
Jing-Dong J. Han
The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
description Phosphatidylinositol 3-kinase catalyzes the reaction from PI(4,5)P2 to PI(3,4,5)P3 and is encoded by the age-1 gene known to regulate lifespan. Here the researchers found that the metabolite myo-inositol, which can be converted to PI(3,4,5)P3 extends worm lifespan and alleviates worm as well as mouse health decline during aging.
format article
author Dawei Shi
Xian Xia
Aoyuan Cui
Zhongxiang Xiong
Yizhen Yan
Jing Luo
Guoyu Chen
Yingying Zeng
Donghong Cai
Lei Hou
Joseph McDermott
Yu Li
Hong Zhang
Jing-Dong J. Han
author_facet Dawei Shi
Xian Xia
Aoyuan Cui
Zhongxiang Xiong
Yizhen Yan
Jing Luo
Guoyu Chen
Yingying Zeng
Donghong Cai
Lei Hou
Joseph McDermott
Yu Li
Hong Zhang
Jing-Dong J. Han
author_sort Dawei Shi
title The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
title_short The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
title_full The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
title_fullStr The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
title_full_unstemmed The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
title_sort precursor of pi(3,4,5)p3 alleviates aging by activating daf-18(pten) and independent of daf-16
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/03dcd5894eac4984b395ddc104128303
work_keys_str_mv AT daweishi theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT xianxia theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT aoyuancui theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT zhongxiangxiong theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT yizhenyan theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT jingluo theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT guoyuchen theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT yingyingzeng theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT donghongcai theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT leihou theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT josephmcdermott theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT yuli theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT hongzhang theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT jingdongjhan theprecursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT daweishi precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT xianxia precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT aoyuancui precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT zhongxiangxiong precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT yizhenyan precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT jingluo precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT guoyuchen precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT yingyingzeng precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT donghongcai precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT leihou precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT josephmcdermott precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT yuli precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT hongzhang precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
AT jingdongjhan precursorofpi345p3alleviatesagingbyactivatingdaf18ptenandindependentofdaf16
_version_ 1718378789458673664

Ejemplares similares