Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder

Abstract Schizophrenia (SZ) and bipolar I disorder (BD-I) share genetic risk factors and cognitive impairments, but these conditions may exhibit differences in cortical functioning associated with inhibitory control. We measured hemodynamic responses during a stop-signal task using near-infrared spe...

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Autores principales:	Noa Tsujii, Wakako Mikawa, Toru Adachi, Tomoyuki Hirose, Osamu Shirakawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03dd8958b06c451b81906f818925dcb3
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spelling	oai:doaj.org-article:03dd8958b06c451b81906f818925dcb32021-12-02T15:08:37ZShared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder10.1038/s41598-018-22929-y2045-2322https://doaj.org/article/03dd8958b06c451b81906f818925dcb32018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22929-yhttps://doaj.org/toc/2045-2322Abstract Schizophrenia (SZ) and bipolar I disorder (BD-I) share genetic risk factors and cognitive impairments, but these conditions may exhibit differences in cortical functioning associated with inhibitory control. We measured hemodynamic responses during a stop-signal task using near-infrared spectroscopy (NIRS) in 20 patients with SZ, 21 patients with BD-I and 18 healthy controls (HCs). We used stop-signal reaction time (SSRT) to estimate behavioural inhibition. Compared with HCs, patients with either SZ or BD-I exhibited significantly reduced activation in the bilateral inferior, middle and superior frontal gyri. Furthermore, patients with BD-I showed inactivation of the right superior temporal gyri compared with patients with SZ or HCs. Patients with SZ or BD-I demonstrated significant negative correlations between SSRT and hemodynamic responses of the right inferior frontal gyrus. Moreover, patients with SZ exhibited correlations in the middle and superior frontal gyri. Our findings suggest that right inferior frontal abnormalities mediate behavioural inhibition impairments in individuals with SZ or BD-I. Differential patterns of orbitofrontal or superior temporal functional abnormalities may reflect important differences in psychopathological features between these disorders.Noa TsujiiWakako MikawaToru AdachiTomoyuki HiroseOsamu ShirakawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noa Tsujii Wakako Mikawa Toru Adachi Tomoyuki Hirose Osamu Shirakawa Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder
description	Abstract Schizophrenia (SZ) and bipolar I disorder (BD-I) share genetic risk factors and cognitive impairments, but these conditions may exhibit differences in cortical functioning associated with inhibitory control. We measured hemodynamic responses during a stop-signal task using near-infrared spectroscopy (NIRS) in 20 patients with SZ, 21 patients with BD-I and 18 healthy controls (HCs). We used stop-signal reaction time (SSRT) to estimate behavioural inhibition. Compared with HCs, patients with either SZ or BD-I exhibited significantly reduced activation in the bilateral inferior, middle and superior frontal gyri. Furthermore, patients with BD-I showed inactivation of the right superior temporal gyri compared with patients with SZ or HCs. Patients with SZ or BD-I demonstrated significant negative correlations between SSRT and hemodynamic responses of the right inferior frontal gyrus. Moreover, patients with SZ exhibited correlations in the middle and superior frontal gyri. Our findings suggest that right inferior frontal abnormalities mediate behavioural inhibition impairments in individuals with SZ or BD-I. Differential patterns of orbitofrontal or superior temporal functional abnormalities may reflect important differences in psychopathological features between these disorders.
format	article
author	Noa Tsujii Wakako Mikawa Toru Adachi Tomoyuki Hirose Osamu Shirakawa
author_facet	Noa Tsujii Wakako Mikawa Toru Adachi Tomoyuki Hirose Osamu Shirakawa
author_sort	Noa Tsujii
title	Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder
title_short	Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder
title_full	Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder
title_fullStr	Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder
title_full_unstemmed	Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder
title_sort	shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/03dd8958b06c451b81906f818925dcb3
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_version_	1718388040428158976

Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder

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