Assessment of a PK/PD Target of Continuous Infusion Beta-Lactams Useful for Preventing Microbiological Failure and/or Resistance Development in Critically Ill Patients Affected by Documented Gram-Negative Infections

Assessment of a PK/PD Target of Continuous Infusion Beta-Lactams Useful for Preventing Microbiological Failure and/or Resistance Development in Critically Ill Patients Affected by Documented Gram-Negative Infections

Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could minimize the occurrence of microbiological failure and/or resistance development. This study aims to assess whether a PK/PD target threshold of continuous infusion (CI) beta-lactams may be useful in preventing mic...

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Bibliographic Details
Main Authors: Milo Gatti, Pier Giorgio Cojutti, Renato Pascale, Tommaso Tonetti, Cristiana Laici, Alessio Dell’Olio, Antonio Siniscalchi, Maddalena Giannella, Pierluigi Viale, Federico Pea
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
PK/PD target attainment
beta-lactams
continuous infusion
critically ill patients
microbiological failure
resistance development
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/03de6b031cb54ca19992da7872528a0a
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https://doaj.org/article/03de6b031cb54ca19992da7872528a0a

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