REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE

Abstract. The comprehensive clinical-immunological characteristic of a tick-borne encephalitis vaccine En-cepur Adult (Germany), which was studied on a group of residents of Far East of Russia was discussed. Reactogenity in 32,4% of vaccinees was characterized by minor clinical manifestations and wa...

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Autores principales:	G. N. Leonova, N. V. Krylova, E. V. Pavlenko, O. S. Maystrovskaya
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	vaccination reactogenity cellular immunity humoral immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/03e51e923b3249fe94f8653d6b34966a
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spelling	oai:doaj.org-article:03e51e923b3249fe94f8653d6b34966a2021-11-18T08:03:42ZREACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE1563-06252313-741X10.15789/1563-0625-2005-4-391-396https://doaj.org/article/03e51e923b3249fe94f8653d6b34966a2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/492https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The comprehensive clinical-immunological characteristic of a tick-borne encephalitis vaccine En-cepur Adult (Germany), which was studied on a group of residents of Far East of Russia was discussed. Reactogenity in 32,4% of vaccinees was characterized by minor clinical manifestations and was due to the reaction to specific vaccine albumin. Expression of immune response (mean geometric titers) was evaluated in a neutralization test. A group with the reactogenity showed higher geometric mean antibody titers (1:182) compared with a group without the reactogenity (1:97).All of vaccinees with various levels (high, middle, low) of specific immune response had an increased quantity of CD20+ and CD25+ lymphocytes. We showed a difference in immunologic reactivity of people with high and low levels of specific antibody response. As compared with a low level group the group with a high level of specific response showed significantly higher quantity of lymphocytes and their subpopulations (CD3+, CD4+, CD45RA+) as well as higher levels of IgM, IgG.We conclude that vaccine Encepur Adult (Germany) possesses a high immunologic activity. It is recommended to use this vaccine as a safe and effective specific preventive remedy in TBE endemic areas.G. N. LeonovaN. V. KrylovaE. V. PavlenkoO. S. MaystrovskayaSPb RAACIarticlevaccinationreactogenitycellular immunityhumoral immunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 4, Pp 391-396 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	vaccination reactogenity cellular immunity humoral immunity Immunologic diseases. Allergy RC581-607
spellingShingle	vaccination reactogenity cellular immunity humoral immunity Immunologic diseases. Allergy RC581-607 G. N. Leonova N. V. Krylova E. V. Pavlenko O. S. Maystrovskaya REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE
description	Abstract. The comprehensive clinical-immunological characteristic of a tick-borne encephalitis vaccine En-cepur Adult (Germany), which was studied on a group of residents of Far East of Russia was discussed. Reactogenity in 32,4% of vaccinees was characterized by minor clinical manifestations and was due to the reaction to specific vaccine albumin. Expression of immune response (mean geometric titers) was evaluated in a neutralization test. A group with the reactogenity showed higher geometric mean antibody titers (1:182) compared with a group without the reactogenity (1:97).All of vaccinees with various levels (high, middle, low) of specific immune response had an increased quantity of CD20+ and CD25+ lymphocytes. We showed a difference in immunologic reactivity of people with high and low levels of specific antibody response. As compared with a low level group the group with a high level of specific response showed significantly higher quantity of lymphocytes and their subpopulations (CD3+, CD4+, CD45RA+) as well as higher levels of IgM, IgG.We conclude that vaccine Encepur Adult (Germany) possesses a high immunologic activity. It is recommended to use this vaccine as a safe and effective specific preventive remedy in TBE endemic areas.
format	article
author	G. N. Leonova N. V. Krylova E. V. Pavlenko O. S. Maystrovskaya
author_facet	G. N. Leonova N. V. Krylova E. V. Pavlenko O. S. Maystrovskaya
author_sort	G. N. Leonova
title	REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE
title_short	REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE
title_full	REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE
title_fullStr	REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE
title_full_unstemmed	REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE
title_sort	reactogenity of tick-borne encephalitis vaccine encepur adult and immune response
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/03e51e923b3249fe94f8653d6b34966a
work_keys_str_mv	AT gnleonova reactogenityoftickborneencephalitisvaccineencepuradultandimmuneresponse AT nvkrylova reactogenityoftickborneencephalitisvaccineencepuradultandimmuneresponse AT evpavlenko reactogenityoftickborneencephalitisvaccineencepuradultandimmuneresponse AT osmaystrovskaya reactogenityoftickborneencephalitisvaccineencepuradultandimmuneresponse
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REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE

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