Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles

Nerea Iturrioz-Rodríguez,1 Miguel A Correa-Duarte,2,3 Mónica L Fanarraga11Nanomedicine Group, University of Cantabria – IDIVAL, Santander, 39011, Spain; 2Department of Physical Chemistry, Center for Biomedical Research (CINBIO), Southern Galicia Institute of Health Re...

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Autores principales: Iturrioz-Rodríguez N, Correa-Duarte MA, Fanarraga ML
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Lenguaje:EN
Publicado: Dove Medical Press 2019
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Acceso en línea:https://doaj.org/article/03e90c363e6442f19896e2f2f95734d0
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spelling oai:doaj.org-article:03e90c363e6442f19896e2f2f95734d02021-12-02T07:33:01ZControlled drug delivery systems for cancer based on mesoporous silica nanoparticles1178-2013https://doaj.org/article/03e90c363e6442f19896e2f2f95734d02019-05-01T00:00:00Zhttps://www.dovepress.com/controlled-drug-delivery-systems-for-cancer-based-on-mesoporous-silica-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nerea Iturrioz-Rodríguez,1 Miguel A Correa-Duarte,2,3 Mónica L Fanarraga11Nanomedicine Group, University of Cantabria – IDIVAL, Santander, 39011, Spain; 2Department of Physical Chemistry, Center for Biomedical Research (CINBIO), Southern Galicia Institute of Health Research (IISGS), Vigo 36310, Spain; 3Biomedical Research Networking Center for Mental Health (CIBERSAM), Universidade de Vigo, Vigo 36310, SpainAbstract: The implementation of nanotechnology in medicine has opened new research horizons particularly in the field of therapeutic delivery. Mesoporous silica particles have emerged as biocompatible drug delivery systems with an enormous potential in the treatment of cancer among many other pathologies. In this review, we focus on the unique properties of these particles as chemotherapy delivery carriers. Here, we summarize the general characteristics of these nanomaterials – including their physicochemical properties and customizable surfaces – different stimuli that can be used to trigger targeted drug release, biocompatibility and finally, the drawbacks of these types of nanomaterials, highlighting some of the most important features of mesoporous silica nanoparticles in drug delivery.Keywords: nanocarrier, drug release, targeted drug delivery, biocompatibility, biodegradability, tumorIturrioz-Rodríguez NCorrea-Duarte MAFanarraga MLDove Medical PressarticleNanocarrierdrug releasetargeted drug deliverybiocompatibilitybiodegradabilitytumour.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3389-3401 (2019)
institution DOAJ
collection DOAJ
language EN
topic Nanocarrier
drug release
targeted drug delivery
biocompatibility
biodegradability
tumour.
Medicine (General)
R5-920
spellingShingle Nanocarrier
drug release
targeted drug delivery
biocompatibility
biodegradability
tumour.
Medicine (General)
R5-920
Iturrioz-Rodríguez N
Correa-Duarte MA
Fanarraga ML
Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
description Nerea Iturrioz-Rodríguez,1 Miguel A Correa-Duarte,2,3 Mónica L Fanarraga11Nanomedicine Group, University of Cantabria – IDIVAL, Santander, 39011, Spain; 2Department of Physical Chemistry, Center for Biomedical Research (CINBIO), Southern Galicia Institute of Health Research (IISGS), Vigo 36310, Spain; 3Biomedical Research Networking Center for Mental Health (CIBERSAM), Universidade de Vigo, Vigo 36310, SpainAbstract: The implementation of nanotechnology in medicine has opened new research horizons particularly in the field of therapeutic delivery. Mesoporous silica particles have emerged as biocompatible drug delivery systems with an enormous potential in the treatment of cancer among many other pathologies. In this review, we focus on the unique properties of these particles as chemotherapy delivery carriers. Here, we summarize the general characteristics of these nanomaterials – including their physicochemical properties and customizable surfaces – different stimuli that can be used to trigger targeted drug release, biocompatibility and finally, the drawbacks of these types of nanomaterials, highlighting some of the most important features of mesoporous silica nanoparticles in drug delivery.Keywords: nanocarrier, drug release, targeted drug delivery, biocompatibility, biodegradability, tumor
format article
author Iturrioz-Rodríguez N
Correa-Duarte MA
Fanarraga ML
author_facet Iturrioz-Rodríguez N
Correa-Duarte MA
Fanarraga ML
author_sort Iturrioz-Rodríguez N
title Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
title_short Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
title_full Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
title_fullStr Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
title_full_unstemmed Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
title_sort controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/03e90c363e6442f19896e2f2f95734d0
work_keys_str_mv AT iturriozrodriguezn controlleddrugdeliverysystemsforcancerbasedonmesoporoussilicananoparticles
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