Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness

Abstract Adaptation to motherhood includes maternal behaviour and lactation during the postpartum period. The major organizing centres of maternal behaviour and lactation are located in the hypothalamic medial preoptic area (MPOA) and the arcuate nucleus, respectively. Insulin-like growth factor I (...

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Autores principales:	András H. Lékó, Melinda Cservenák, Éva Rebeka Szabó, János Hanics, Alán Alpár, Árpád Dobolyi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03efc2641340475c9678e82a73f930ee
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spelling	oai:doaj.org-article:03efc2641340475c9678e82a73f930ee2021-12-02T12:30:37ZInsulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness10.1038/s41598-017-03645-52045-2322https://doaj.org/article/03efc2641340475c9678e82a73f930ee2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03645-5https://doaj.org/toc/2045-2322Abstract Adaptation to motherhood includes maternal behaviour and lactation during the postpartum period. The major organizing centres of maternal behaviour and lactation are located in the hypothalamic medial preoptic area (MPOA) and the arcuate nucleus, respectively. Insulin-like growth factor I (IGF-I) is an effector of the growth hormone axis; however, its function in the brain is largely unexplored. We identified increased maternal IGF binding protein-3 (IGFBP-3) expression in preoptic rat microarray data and confirmed it by RT-PCR. In situ hybridization histochemistry showed markedly elevated IGFBP-3 expression in the MPOA and the arcuate nucleus in rat dams. Prolonged intracerebroventricular injection of IGF-I or antagonism of brain IGFBP-3 with an inhibitor (NBI-31772) using osmotic minipumps increased pup retrieval time, suggesting reduced maternal motivation. Suckling-induced prolactin release and pup weight gain were also suppressed by IGF-I, suggesting reduced lactation. In addition, IGF-I-induced tyrosine hydroxylase expression and its specific phosphorylation in tuberoinfundibular dopaminergic neurons suppress prolactin secretion. Thus, IGF-I may inhibit both behavioural and lactational alterations in mothers. Neurons in the MPOA and arcuate nuclei express IGFBP-3 during the postpartum period to neutralize IGF-I effects. IGFBP-3 can prevent the blockade of maternal behaviour and lactation exerted by IGF-I, suggesting a novel modulatory mechanism underlying the behavioural and hormonal effects during central maternal adaptations.András H. LékóMelinda CservenákÉva Rebeka SzabóJános HanicsAlán AlpárÁrpád DobolyiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q András H. Lékó Melinda Cservenák Éva Rebeka Szabó János Hanics Alán Alpár Árpád Dobolyi Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness
description	Abstract Adaptation to motherhood includes maternal behaviour and lactation during the postpartum period. The major organizing centres of maternal behaviour and lactation are located in the hypothalamic medial preoptic area (MPOA) and the arcuate nucleus, respectively. Insulin-like growth factor I (IGF-I) is an effector of the growth hormone axis; however, its function in the brain is largely unexplored. We identified increased maternal IGF binding protein-3 (IGFBP-3) expression in preoptic rat microarray data and confirmed it by RT-PCR. In situ hybridization histochemistry showed markedly elevated IGFBP-3 expression in the MPOA and the arcuate nucleus in rat dams. Prolonged intracerebroventricular injection of IGF-I or antagonism of brain IGFBP-3 with an inhibitor (NBI-31772) using osmotic minipumps increased pup retrieval time, suggesting reduced maternal motivation. Suckling-induced prolactin release and pup weight gain were also suppressed by IGF-I, suggesting reduced lactation. In addition, IGF-I-induced tyrosine hydroxylase expression and its specific phosphorylation in tuberoinfundibular dopaminergic neurons suppress prolactin secretion. Thus, IGF-I may inhibit both behavioural and lactational alterations in mothers. Neurons in the MPOA and arcuate nuclei express IGFBP-3 during the postpartum period to neutralize IGF-I effects. IGFBP-3 can prevent the blockade of maternal behaviour and lactation exerted by IGF-I, suggesting a novel modulatory mechanism underlying the behavioural and hormonal effects during central maternal adaptations.
format	article
author	András H. Lékó Melinda Cservenák Éva Rebeka Szabó János Hanics Alán Alpár Árpád Dobolyi
author_facet	András H. Lékó Melinda Cservenák Éva Rebeka Szabó János Hanics Alán Alpár Árpád Dobolyi
author_sort	András H. Lékó
title	Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness
title_short	Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness
title_full	Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness
title_fullStr	Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness
title_full_unstemmed	Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness
title_sort	insulin-like growth factor i and its binding protein-3 are regulators of lactation and maternal responsiveness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/03efc2641340475c9678e82a73f930ee
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Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness

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