Age-related differences and sexual dimorphism in canine sleep spindles

Abstract Non-REM bursts of activity in the sigma range (9–16 Hz) typical of sleep spindles predict learning in dogs, similar to humans and rats. Little is known, however, about the age-related changes in amplitude, density (spindles/minute) and frequency (waves/second) of canine spindles. We investi...

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Autores principales:	Ivaylo Borislavov Iotchev, Anna Kis, Borbála Turcsán, Daniel Rodrigo Tejeda Fernández de Lara, Vivien Reicher, Enikő Kubinyi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03f05717368149a9b5e19ae3bea5769c
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spelling	oai:doaj.org-article:03f05717368149a9b5e19ae3bea5769c2021-12-02T15:09:46ZAge-related differences and sexual dimorphism in canine sleep spindles10.1038/s41598-019-46434-y2045-2322https://doaj.org/article/03f05717368149a9b5e19ae3bea5769c2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46434-yhttps://doaj.org/toc/2045-2322Abstract Non-REM bursts of activity in the sigma range (9–16 Hz) typical of sleep spindles predict learning in dogs, similar to humans and rats. Little is known, however, about the age-related changes in amplitude, density (spindles/minute) and frequency (waves/second) of canine spindles. We investigated a large sample (N = 155) of intact and neutered pet dogs of both sexes, varying in breed and age, searching for spindles in segments of non-REM sleep. We recorded EEG from both a frontal midline electrode (Fz) and a central midline electrode (Cz) in 55.5% of the dogs, in the remaining animals only the Fz electrode was active (bipolar derivation). A similar topography was observed for fast (≥13 Hz) spindle occurrence as in humans (fast spindle number, density on Cz > Fz). For fast spindles, density was higher in females, and increased with age. These effects were more pronounced among intact animals and on Fz. Slow spindle density declined and fast spindle frequency increased with age on Cz, while on Fz age-related amplitude decline was observed. The frequency of fast spindles on Fz and slow spindles on Cz was linked to both sex and neutering, suggesting modulation by sexual hormones. Intact females displayed higher frequencies than males and neutered females. Our findings support the argument that sigma bursts in the canine non-REM sleep are analogous to human sleep spindles, and suggest that slow and fast spindles display different trajectories related to age, of which an increase in frontal fast spindles is unique to dogs.Ivaylo Borislavov IotchevAnna KisBorbála TurcsánDaniel Rodrigo Tejeda Fernández de LaraVivien ReicherEnikő KubinyiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ivaylo Borislavov Iotchev Anna Kis Borbála Turcsán Daniel Rodrigo Tejeda Fernández de Lara Vivien Reicher Enikő Kubinyi Age-related differences and sexual dimorphism in canine sleep spindles
description	Abstract Non-REM bursts of activity in the sigma range (9–16 Hz) typical of sleep spindles predict learning in dogs, similar to humans and rats. Little is known, however, about the age-related changes in amplitude, density (spindles/minute) and frequency (waves/second) of canine spindles. We investigated a large sample (N = 155) of intact and neutered pet dogs of both sexes, varying in breed and age, searching for spindles in segments of non-REM sleep. We recorded EEG from both a frontal midline electrode (Fz) and a central midline electrode (Cz) in 55.5% of the dogs, in the remaining animals only the Fz electrode was active (bipolar derivation). A similar topography was observed for fast (≥13 Hz) spindle occurrence as in humans (fast spindle number, density on Cz > Fz). For fast spindles, density was higher in females, and increased with age. These effects were more pronounced among intact animals and on Fz. Slow spindle density declined and fast spindle frequency increased with age on Cz, while on Fz age-related amplitude decline was observed. The frequency of fast spindles on Fz and slow spindles on Cz was linked to both sex and neutering, suggesting modulation by sexual hormones. Intact females displayed higher frequencies than males and neutered females. Our findings support the argument that sigma bursts in the canine non-REM sleep are analogous to human sleep spindles, and suggest that slow and fast spindles display different trajectories related to age, of which an increase in frontal fast spindles is unique to dogs.
format	article
author	Ivaylo Borislavov Iotchev Anna Kis Borbála Turcsán Daniel Rodrigo Tejeda Fernández de Lara Vivien Reicher Enikő Kubinyi
author_facet	Ivaylo Borislavov Iotchev Anna Kis Borbála Turcsán Daniel Rodrigo Tejeda Fernández de Lara Vivien Reicher Enikő Kubinyi
author_sort	Ivaylo Borislavov Iotchev
title	Age-related differences and sexual dimorphism in canine sleep spindles
title_short	Age-related differences and sexual dimorphism in canine sleep spindles
title_full	Age-related differences and sexual dimorphism in canine sleep spindles
title_fullStr	Age-related differences and sexual dimorphism in canine sleep spindles
title_full_unstemmed	Age-related differences and sexual dimorphism in canine sleep spindles
title_sort	age-related differences and sexual dimorphism in canine sleep spindles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/03f05717368149a9b5e19ae3bea5769c
work_keys_str_mv	AT ivayloborislavoviotchev agerelateddifferencesandsexualdimorphismincaninesleepspindles AT annakis agerelateddifferencesandsexualdimorphismincaninesleepspindles AT borbalaturcsan agerelateddifferencesandsexualdimorphismincaninesleepspindles AT danielrodrigotejedafernandezdelara agerelateddifferencesandsexualdimorphismincaninesleepspindles AT vivienreicher agerelateddifferencesandsexualdimorphismincaninesleepspindles AT enikokubinyi agerelateddifferencesandsexualdimorphismincaninesleepspindles
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Age-related differences and sexual dimorphism in canine sleep spindles

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