Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers

Cancer is one of the most common causes of death worldwide, and its development is a result of the complex interaction of genetic factors, environmental cues, and aging. Hormone-sensitive cancers depend on the action of one or more hormones for their development and progression. Sex steroids and cor...

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Autores principales:	Mirco Masi, Marco Racchi, Cristina Travelli, Emanuela Corsini, Erica Buoso
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ZIP9 OXER1 GPRC6A TRPM8 GPER mPR Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/03f1fd20eb4f4756a62735b8b327940b
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spelling	oai:doaj.org-article:03f1fd20eb4f4756a62735b8b327940b2021-11-25T17:10:16ZMolecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers10.3390/cells101129992073-4409https://doaj.org/article/03f1fd20eb4f4756a62735b8b327940b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2999https://doaj.org/toc/2073-4409Cancer is one of the most common causes of death worldwide, and its development is a result of the complex interaction of genetic factors, environmental cues, and aging. Hormone-sensitive cancers depend on the action of one or more hormones for their development and progression. Sex steroids and corticosteroids can regulate different physiological functions, including metabolism, growth, and proliferation, through their interaction with specific nuclear receptors, that can transcriptionally regulate target genes via their genomic actions. Therefore, interference with hormones’ activities, e.g., deregulation of their production and downstream pathways or the exposition to exogenous hormone-active substances such as endocrine-disrupting chemicals (EDCs), can affect the regulation of their correlated pathways and trigger the neoplastic transformation. Although nuclear receptors account for most hormone-related biologic effects and their slow genomic responses are well-studied, less-known membrane receptors are emerging for their ability to mediate steroid hormones effects through the activation of rapid non-genomic responses also involved in the development of hormone-sensitive cancers. This review aims to collect pre-clinical and clinical data on these extranuclear receptors not only to draw attention to their emerging role in cancer development and progression but also to highlight their dual role as tumor microenvironment players and potential candidate drug targets.Mirco MasiMarco RacchiCristina TravelliEmanuela CorsiniErica BuosoMDPI AGarticleZIP9OXER1GPRC6ATRPM8GPERmPRBiology (General)QH301-705.5ENCells, Vol 10, Iss 2999, p 2999 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ZIP9 OXER1 GPRC6A TRPM8 GPER mPR Biology (General) QH301-705.5
spellingShingle	ZIP9 OXER1 GPRC6A TRPM8 GPER mPR Biology (General) QH301-705.5 Mirco Masi Marco Racchi Cristina Travelli Emanuela Corsini Erica Buoso Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
description	Cancer is one of the most common causes of death worldwide, and its development is a result of the complex interaction of genetic factors, environmental cues, and aging. Hormone-sensitive cancers depend on the action of one or more hormones for their development and progression. Sex steroids and corticosteroids can regulate different physiological functions, including metabolism, growth, and proliferation, through their interaction with specific nuclear receptors, that can transcriptionally regulate target genes via their genomic actions. Therefore, interference with hormones’ activities, e.g., deregulation of their production and downstream pathways or the exposition to exogenous hormone-active substances such as endocrine-disrupting chemicals (EDCs), can affect the regulation of their correlated pathways and trigger the neoplastic transformation. Although nuclear receptors account for most hormone-related biologic effects and their slow genomic responses are well-studied, less-known membrane receptors are emerging for their ability to mediate steroid hormones effects through the activation of rapid non-genomic responses also involved in the development of hormone-sensitive cancers. This review aims to collect pre-clinical and clinical data on these extranuclear receptors not only to draw attention to their emerging role in cancer development and progression but also to highlight their dual role as tumor microenvironment players and potential candidate drug targets.
format	article
author	Mirco Masi Marco Racchi Cristina Travelli Emanuela Corsini Erica Buoso
author_facet	Mirco Masi Marco Racchi Cristina Travelli Emanuela Corsini Erica Buoso
author_sort	Mirco Masi
title	Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
title_short	Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
title_full	Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
title_fullStr	Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
title_full_unstemmed	Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
title_sort	molecular characterization of membrane steroid receptors in hormone-sensitive cancers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/03f1fd20eb4f4756a62735b8b327940b
work_keys_str_mv	AT mircomasi molecularcharacterizationofmembranesteroidreceptorsinhormonesensitivecancers AT marcoracchi molecularcharacterizationofmembranesteroidreceptorsinhormonesensitivecancers AT cristinatravelli molecularcharacterizationofmembranesteroidreceptorsinhormonesensitivecancers AT emanuelacorsini molecularcharacterizationofmembranesteroidreceptorsinhormonesensitivecancers AT ericabuoso molecularcharacterizationofmembranesteroidreceptorsinhormonesensitivecancers
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Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers

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