Dutch population structure across space, time and GWAS design

Genetic variation in modern humans can reveal information about a population’s history and migration patterns. Here, the authors describe the ancestry and geospatial genetic structure of the Netherlands, and demonstrate the utility of haplotype-based covariates in genome-wide association studies.

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Detalles Bibliográficos
Autores principales: Ross P. Byrne, Wouter van Rheenen, Project MinE ALS GWAS Consortium, Leonard H. van den Berg, Jan H. Veldink, Russell L. McLaughlin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/03f3a68c977f4d85996f5fe59dbf86ba
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Descripción
Sumario:Genetic variation in modern humans can reveal information about a population’s history and migration patterns. Here, the authors describe the ancestry and geospatial genetic structure of the Netherlands, and demonstrate the utility of haplotype-based covariates in genome-wide association studies.