Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Epigenetic perturbations may be an important factor in diseases where both genes and environment play a role. Here, Ventham and colleagues show that DNA methylation changes in inflammatory bowel disease are related to the underlying genotype, and are associated with cell-specific changes to gene exp...

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Autores principales:	N. T. Ventham, N. A. Kennedy, A. T. Adams, R. Kalla, S. Heath, K. R. O'Leary, H. Drummond, IBD BIOM consortium, IBD CHARACTER consortium, D. C. Wilson, I. G. Gut, E. R. Nimmo, J. Satsangi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03f4cfccee3b45d1b75ae6adcb9da079
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spelling	oai:doaj.org-article:03f4cfccee3b45d1b75ae6adcb9da0792021-12-02T16:49:25ZIntegrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease10.1038/ncomms135072041-1723https://doaj.org/article/03f4cfccee3b45d1b75ae6adcb9da0792016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13507https://doaj.org/toc/2041-1723Epigenetic perturbations may be an important factor in diseases where both genes and environment play a role. Here, Ventham and colleagues show that DNA methylation changes in inflammatory bowel disease are related to the underlying genotype, and are associated with cell-specific changes to gene expression.N. T. VenthamN. A. KennedyA. T. AdamsR. KallaS. HeathK. R. O'LearyH. DrummondIBD BIOM consortiumIBD CHARACTER consortiumD. C. WilsonI. G. GutE. R. NimmoJ. SatsangiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. T. Ventham N. A. Kennedy A. T. Adams R. Kalla S. Heath K. R. O'Leary H. Drummond IBD BIOM consortium IBD CHARACTER consortium D. C. Wilson I. G. Gut E. R. Nimmo J. Satsangi Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
description	Epigenetic perturbations may be an important factor in diseases where both genes and environment play a role. Here, Ventham and colleagues show that DNA methylation changes in inflammatory bowel disease are related to the underlying genotype, and are associated with cell-specific changes to gene expression.
format	article
author	N. T. Ventham N. A. Kennedy A. T. Adams R. Kalla S. Heath K. R. O'Leary H. Drummond IBD BIOM consortium IBD CHARACTER consortium D. C. Wilson I. G. Gut E. R. Nimmo J. Satsangi
author_facet	N. T. Ventham N. A. Kennedy A. T. Adams R. Kalla S. Heath K. R. O'Leary H. Drummond IBD BIOM consortium IBD CHARACTER consortium D. C. Wilson I. G. Gut E. R. Nimmo J. Satsangi
author_sort	N. T. Ventham
title	Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
title_short	Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
title_full	Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
title_fullStr	Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
title_full_unstemmed	Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
title_sort	integrative epigenome-wide analysis demonstrates that dna methylation may mediate genetic risk in inflammatory bowel disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/03f4cfccee3b45d1b75ae6adcb9da079
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Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

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