ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS

Antibodies to the cytoplasm of neutrophils (p-ANCA) are detectable in 67% of patients with ulcerative colitis (UC). We have revealed typical clinical features of the patients with diagnostic p-ANCA titer, i.e., longer disease duration, prolonged fevers, and increased stool frequency. Moreover, throm...

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Autores principales:	A. G. Kharitonov, E. A. Kondrashina, A. Yu. Baranovsky, T. V. Bulgakova, S. V. Lapin, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	p-anca ulcerative colitis antibodies prognosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/03f59c4007354dbf8580f3c619acab42
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spelling	oai:doaj.org-article:03f59c4007354dbf8580f3c619acab422021-11-18T08:03:41ZANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS1563-06252313-741X10.15789/1563-0625-2010-6-537-546https://doaj.org/article/03f59c4007354dbf8580f3c619acab422014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/469https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAntibodies to the cytoplasm of neutrophils (p-ANCA) are detectable in 67% of patients with ulcerative colitis (UC). We have revealed typical clinical features of the patients with diagnostic p-ANCA titer, i.e., longer disease duration, prolonged fevers, and increased stool frequency. Moreover, thrombocytosis, leukocytosis and hypoalbuminemia are more common in this group. By endoscopic examination, mucosal ulcers of the colon are significantly more frequent in this group of patients. We have also noted higher rates of severe and relapsing cases among p-ANCA-positive patients. The data obtained allow us to suggest that the diagnostic titers of p-ANCA are predictive for unfavorable prognosis in UC.A. G. KharitonovE. A. KondrashinaA. Yu. BaranovskyT. V. BulgakovaS. V. LapinAreg A. TotolianSPb RAACIarticlep-ancaulcerative colitisantibodiesprognosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 6, Pp 537-546 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	p-anca ulcerative colitis antibodies prognosis Immunologic diseases. Allergy RC581-607
spellingShingle	p-anca ulcerative colitis antibodies prognosis Immunologic diseases. Allergy RC581-607 A. G. Kharitonov E. A. Kondrashina A. Yu. Baranovsky T. V. Bulgakova S. V. Lapin Areg A. Totolian ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS
description	Antibodies to the cytoplasm of neutrophils (p-ANCA) are detectable in 67% of patients with ulcerative colitis (UC). We have revealed typical clinical features of the patients with diagnostic p-ANCA titer, i.e., longer disease duration, prolonged fevers, and increased stool frequency. Moreover, thrombocytosis, leukocytosis and hypoalbuminemia are more common in this group. By endoscopic examination, mucosal ulcers of the colon are significantly more frequent in this group of patients. We have also noted higher rates of severe and relapsing cases among p-ANCA-positive patients. The data obtained allow us to suggest that the diagnostic titers of p-ANCA are predictive for unfavorable prognosis in UC.
format	article
author	A. G. Kharitonov E. A. Kondrashina A. Yu. Baranovsky T. V. Bulgakova S. V. Lapin Areg A. Totolian
author_facet	A. G. Kharitonov E. A. Kondrashina A. Yu. Baranovsky T. V. Bulgakova S. V. Lapin Areg A. Totolian
author_sort	A. G. Kharitonov
title	ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS
title_short	ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS
title_full	ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS
title_fullStr	ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS
title_full_unstemmed	ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS
title_sort	antibodies to the cytoplasm of neutrophils: a marker of unfavorable clinical course in non-specific ulcerative colitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/03f59c4007354dbf8580f3c619acab42
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ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS

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