Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facil...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Laurent Chorro, Masako Suzuki, Shu Shien Chin, Tere M. Williams, Erik L. Snapp, Livia Odagiu, Nathalie Labrecque, Grégoire Lauvau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/03fa6c64169946b19425edd4352c9b39
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:03fa6c64169946b19425edd4352c9b39
record_format	dspace
spelling	oai:doaj.org-article:03fa6c64169946b19425edd4352c9b392021-12-02T15:33:46ZInterleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape10.1038/s41467-018-07806-62041-1723https://doaj.org/article/03fa6c64169946b19425edd4352c9b392018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07806-6https://doaj.org/toc/2041-1723Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facilitate Treg cell lineage commitment in the thymus.Laurent ChorroMasako SuzukiShu Shien ChinTere M. WilliamsErik L. SnappLivia OdagiuNathalie LabrecqueGrégoire LauvauNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laurent Chorro Masako Suzuki Shu Shien Chin Tere M. Williams Erik L. Snapp Livia Odagiu Nathalie Labrecque Grégoire Lauvau Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
description	Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facilitate Treg cell lineage commitment in the thymus.
format	article
author	Laurent Chorro Masako Suzuki Shu Shien Chin Tere M. Williams Erik L. Snapp Livia Odagiu Nathalie Labrecque Grégoire Lauvau
author_facet	Laurent Chorro Masako Suzuki Shu Shien Chin Tere M. Williams Erik L. Snapp Livia Odagiu Nathalie Labrecque Grégoire Lauvau
author_sort	Laurent Chorro
title	Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
title_short	Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
title_full	Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
title_fullStr	Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
title_full_unstemmed	Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
title_sort	interleukin 2 modulates thymic-derived regulatory t cell epigenetic landscape
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/03fa6c64169946b19425edd4352c9b39
work_keys_str_mv	AT laurentchorro interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape AT masakosuzuki interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape AT shushienchin interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape AT teremwilliams interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape AT eriklsnapp interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape AT liviaodagiu interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape AT nathalielabrecque interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape AT gregoirelauvau interleukin2modulatesthymicderivedregulatorytcellepigeneticlandscape
_version_	1718387002971258880

Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

Ejemplares similares