Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facil...

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Autores principales: Laurent Chorro, Masako Suzuki, Shu Shien Chin, Tere M. Williams, Erik L. Snapp, Livia Odagiu, Nathalie Labrecque, Grégoire Lauvau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/03fa6c64169946b19425edd4352c9b39
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