Circulating levels of growth hormone in postural orthostatic tachycardia syndrome

Abstract Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder with poorly understood etiology and underlying pathophysiology. Since cardiovascular morbidity has been linked to growth hormone (GH), we studied GH levels in patients with POTS. We conducted an age-sex-...

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Autores principales:	Madeleine Johansson, Fabrizio Ricci, Janin Schulte, Margaretha Persson, Olle Melander, Richard Sutton, Viktor Hamrefors, Artur Fedorowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/03fcc4d6f5be44cfa2392a3497e6b1f0
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spelling	oai:doaj.org-article:03fcc4d6f5be44cfa2392a3497e6b1f02021-12-02T17:32:59ZCirculating levels of growth hormone in postural orthostatic tachycardia syndrome10.1038/s41598-021-87983-52045-2322https://doaj.org/article/03fcc4d6f5be44cfa2392a3497e6b1f02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87983-5https://doaj.org/toc/2045-2322Abstract Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder with poorly understood etiology and underlying pathophysiology. Since cardiovascular morbidity has been linked to growth hormone (GH), we studied GH levels in patients with POTS. We conducted an age-sex-matched case–control study in patients with POTS (age 31 ± 9 years; n = 42) and healthy controls (32 ± 9 years; n = 46). Plasma GH levels were measured using high-sensitivity chemiluminescence sandwich immunoassay. The burden of orthostatic intolerance symptoms was assessed by the Orthostatic Hypotension Questionnaire (OHQ), consisting of a symptom assessment scale (OHSA) and a daily activity scale (OHDAS). POTS patients had significantly higher composite OHQ score than controls, more symptoms and less activity. Supine heart rate and diastolic blood pressure (BP), but not systolic BP, were significantly higher in POTS. Median plasma GH levels were significantly lower in POTS (0.53 ng/mL) than controls (2.33 ng/mL, p = 0.04). GH levels were inversely related to OHDAS in POTS and supine systolic BP in POTS and controls, but not heart rate neither group. POTS is associated with lower GH levels. Impairment of daily life activities is inversely related with GH in POTS. A higher supine diastolic BP is inversely associated with GH levels in POTS and healthy individuals.Madeleine JohanssonFabrizio RicciJanin SchulteMargaretha PerssonOlle MelanderRichard SuttonViktor HamreforsArtur FedorowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Madeleine Johansson Fabrizio Ricci Janin Schulte Margaretha Persson Olle Melander Richard Sutton Viktor Hamrefors Artur Fedorowski Circulating levels of growth hormone in postural orthostatic tachycardia syndrome
description	Abstract Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder with poorly understood etiology and underlying pathophysiology. Since cardiovascular morbidity has been linked to growth hormone (GH), we studied GH levels in patients with POTS. We conducted an age-sex-matched case–control study in patients with POTS (age 31 ± 9 years; n = 42) and healthy controls (32 ± 9 years; n = 46). Plasma GH levels were measured using high-sensitivity chemiluminescence sandwich immunoassay. The burden of orthostatic intolerance symptoms was assessed by the Orthostatic Hypotension Questionnaire (OHQ), consisting of a symptom assessment scale (OHSA) and a daily activity scale (OHDAS). POTS patients had significantly higher composite OHQ score than controls, more symptoms and less activity. Supine heart rate and diastolic blood pressure (BP), but not systolic BP, were significantly higher in POTS. Median plasma GH levels were significantly lower in POTS (0.53 ng/mL) than controls (2.33 ng/mL, p = 0.04). GH levels were inversely related to OHDAS in POTS and supine systolic BP in POTS and controls, but not heart rate neither group. POTS is associated with lower GH levels. Impairment of daily life activities is inversely related with GH in POTS. A higher supine diastolic BP is inversely associated with GH levels in POTS and healthy individuals.
format	article
author	Madeleine Johansson Fabrizio Ricci Janin Schulte Margaretha Persson Olle Melander Richard Sutton Viktor Hamrefors Artur Fedorowski
author_facet	Madeleine Johansson Fabrizio Ricci Janin Schulte Margaretha Persson Olle Melander Richard Sutton Viktor Hamrefors Artur Fedorowski
author_sort	Madeleine Johansson
title	Circulating levels of growth hormone in postural orthostatic tachycardia syndrome
title_short	Circulating levels of growth hormone in postural orthostatic tachycardia syndrome
title_full	Circulating levels of growth hormone in postural orthostatic tachycardia syndrome
title_fullStr	Circulating levels of growth hormone in postural orthostatic tachycardia syndrome
title_full_unstemmed	Circulating levels of growth hormone in postural orthostatic tachycardia syndrome
title_sort	circulating levels of growth hormone in postural orthostatic tachycardia syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/03fcc4d6f5be44cfa2392a3497e6b1f0
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Circulating levels of growth hormone in postural orthostatic tachycardia syndrome

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