EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS

Abstract. Мonocytes in feto-placental circulation are exposed to factors secreted by placental tissue. These factors influence monocyte functions in pregnancy. In present study, an in vitro model (monocyte-like THP-1 cells) was used for assessing effects of soluble placental factors obtained from wo...

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Autores principales:	Ya. S. Onokhina, T. Yu. Lvova, D. Z. Tzitzkarava, S. A. Selkov, D. I. Sokolov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	monocytes macrophages cytokines placenta preeclampsia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/03ff6e2eb6af4cf3a580678e536499f7
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spelling	oai:doaj.org-article:03ff6e2eb6af4cf3a580678e536499f72021-11-18T08:03:43ZEFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS1563-06252313-741X10.15789/1563-0625-2013-3-227-234https://doaj.org/article/03ff6e2eb6af4cf3a580678e536499f72014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/631https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Мonocytes in feto-placental circulation are exposed to factors secreted by placental tissue. These factors influence monocyte functions in pregnancy. In present study, an in vitro model (monocyte-like THP-1 cells) was used for assessing effects of soluble placental factors obtained from women with physiological pregnancies, or preeclampsia cases. The following effects of placental factors were revealed: increased secretion of VEGF by THP-1 cells along with decreased secretion of IL-6, IL-8 and MCP-1 under the influence of placental factors from the I. trimester of pregnancy in comparison with III. trimester. Secretion of IL-6 and MCP-1 by THP-1 cells was increased, and secretion of soluble TNFRII was decreased upon co-cultivation with soluble placental factors from the women with preeclampsia, as compared with placental products from physiological pregnancies.The work is supported by grants ГК № 02.740.11.0711 from Ministry of Education and Science, and НШ-3594.2010.7 grant from the President of Russian Federation.Ya. S. OnokhinaT. Yu. LvovaD. Z. TzitzkaravaS. A. SelkovD. I. SokolovSPb RAACIarticlemonocytesmacrophagescytokinesplacentapreeclampsiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 3, Pp 227-234 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	monocytes macrophages cytokines placenta preeclampsia Immunologic diseases. Allergy RC581-607
spellingShingle	monocytes macrophages cytokines placenta preeclampsia Immunologic diseases. Allergy RC581-607 Ya. S. Onokhina T. Yu. Lvova D. Z. Tzitzkarava S. A. Selkov D. I. Sokolov EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS
description	Abstract. Мonocytes in feto-placental circulation are exposed to factors secreted by placental tissue. These factors influence monocyte functions in pregnancy. In present study, an in vitro model (monocyte-like THP-1 cells) was used for assessing effects of soluble placental factors obtained from women with physiological pregnancies, or preeclampsia cases. The following effects of placental factors were revealed: increased secretion of VEGF by THP-1 cells along with decreased secretion of IL-6, IL-8 and MCP-1 under the influence of placental factors from the I. trimester of pregnancy in comparison with III. trimester. Secretion of IL-6 and MCP-1 by THP-1 cells was increased, and secretion of soluble TNFRII was decreased upon co-cultivation with soluble placental factors from the women with preeclampsia, as compared with placental products from physiological pregnancies.The work is supported by grants ГК № 02.740.11.0711 from Ministry of Education and Science, and НШ-3594.2010.7 grant from the President of Russian Federation.
format	article
author	Ya. S. Onokhina T. Yu. Lvova D. Z. Tzitzkarava S. A. Selkov D. I. Sokolov
author_facet	Ya. S. Onokhina T. Yu. Lvova D. Z. Tzitzkarava S. A. Selkov D. I. Sokolov
author_sort	Ya. S. Onokhina
title	EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS
title_short	EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS
title_full	EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS
title_fullStr	EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS
title_full_unstemmed	EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS
title_sort	effects of secretable placental factors upon secretion of cytokines by thp-1 monocyte-like cells
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/03ff6e2eb6af4cf3a580678e536499f7
work_keys_str_mv	AT yasonokhina effectsofsecretableplacentalfactorsuponsecretionofcytokinesbythp1monocytelikecells AT tyulvova effectsofsecretableplacentalfactorsuponsecretionofcytokinesbythp1monocytelikecells AT dztzitzkarava effectsofsecretableplacentalfactorsuponsecretionofcytokinesbythp1monocytelikecells AT saselkov effectsofsecretableplacentalfactorsuponsecretionofcytokinesbythp1monocytelikecells AT disokolov effectsofsecretableplacentalfactorsuponsecretionofcytokinesbythp1monocytelikecells
_version_	1718422460228960256

EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS

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