A little CFTR goes a long way: CFTR-dependent sweat secretion from G551D and R117H-5T cystic fibrosis subjects taking ivacaftor.
To determine if oral dosing with the CFTR-potentiator ivacaftor (VX-770, Kalydeco) improves CFTR-dependent sweating in CF subjects carrying G551D or R117H-5T mutations, we optically measured sweat secretion from 32-143 individually identified glands in each of 8 CF subjects; 6 F508del/G551D, one G55...
Guardado en:
Autores principales: | Jessica E Char, Marlene H Wolfe, Hyung-Ju Cho, Il-Ho Park, Jin Hyeok Jeong, Eric Frisbee, Colleen Dunn, Zoe Davies, Carlos Milla, Richard B Moss, Ewart A C Thomas, Jeffrey J Wine |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0401acd3a79e4cd98a0cdfc673e9e1c9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment
por: Ciaran A. Shaughnessy, et al.
Publicado: (2021) -
CFTR Protein: Not Just a Chloride Channel?
por: Laurence S. Hanssens, et al.
Publicado: (2021) -
Impact of Airway Inflammation on the Efficacy of CFTR Modulators
por: Carla M. P. Ribeiro, et al.
Publicado: (2021) -
The Distribution and Role of the CFTR Protein in the Intracellular Compartments
por: Agnieszka Lukasiak, et al.
Publicado: (2021) -
Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators
por: Iwona M. Pranke, et al.
Publicado: (2017)