A transcribed enhancer dictates mesendoderm specification in pluripotency

A transcribed enhancer dictates mesendoderm specification in pluripotency

Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling...

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Auteurs principaux: Michael Alexanian, Daniel Maric, Stephen P. Jenkinson, Marco Mina, Clayton E. Friedman, Ching-Chia Ting, Rudi Micheletti, Isabelle Plaisance, Mohamed Nemir, Damien Maison, Jasmin Kernen, Iole Pezzuto, Dominic Villeneuve, Frédéric Burdet, Mark Ibberson, Stephen L. Leib, Nathan J. Palpant, Nouria Hernandez, Samir Ounzain, Thierry Pedrazzini
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
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Accès en ligne:https://doaj.org/article/0401f32188554c209d1d26fb94e3d2e8
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Résumé:Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling adoption of the mesendodermal cell fate.

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