A transcribed enhancer dictates mesendoderm specification in pluripotency

Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling...

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Autores principales:	Michael Alexanian, Daniel Maric, Stephen P. Jenkinson, Marco Mina, Clayton E. Friedman, Ching-Chia Ting, Rudi Micheletti, Isabelle Plaisance, Mohamed Nemir, Damien Maison, Jasmin Kernen, Iole Pezzuto, Dominic Villeneuve, Frédéric Burdet, Mark Ibberson, Stephen L. Leib, Nathan J. Palpant, Nouria Hernandez, Samir Ounzain, Thierry Pedrazzini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0401f32188554c209d1d26fb94e3d2e8
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spelling	oai:doaj.org-article:0401f32188554c209d1d26fb94e3d2e82021-12-02T15:38:56ZA transcribed enhancer dictates mesendoderm specification in pluripotency10.1038/s41467-017-01804-w2041-1723https://doaj.org/article/0401f32188554c209d1d26fb94e3d2e82017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01804-whttps://doaj.org/toc/2041-1723Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling adoption of the mesendodermal cell fate.Michael AlexanianDaniel MaricStephen P. JenkinsonMarco MinaClayton E. FriedmanChing-Chia TingRudi MichelettiIsabelle PlaisanceMohamed NemirDamien MaisonJasmin KernenIole PezzutoDominic VilleneuveFrédéric BurdetMark IbbersonStephen L. LeibNathan J. PalpantNouria HernandezSamir OunzainThierry PedrazziniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Alexanian Daniel Maric Stephen P. Jenkinson Marco Mina Clayton E. Friedman Ching-Chia Ting Rudi Micheletti Isabelle Plaisance Mohamed Nemir Damien Maison Jasmin Kernen Iole Pezzuto Dominic Villeneuve Frédéric Burdet Mark Ibberson Stephen L. Leib Nathan J. Palpant Nouria Hernandez Samir Ounzain Thierry Pedrazzini A transcribed enhancer dictates mesendoderm specification in pluripotency
description	Long noncoding RNAs (lncRNAs) are key regulators of lineage specification during development. Here, the authors investigate remodeling of enhancers and regulation of the lncRNA transcriptome during mesendoderm specification, and identify a pluripotent stage-specific transcribed enhancer controlling adoption of the mesendodermal cell fate.
format	article
author	Michael Alexanian Daniel Maric Stephen P. Jenkinson Marco Mina Clayton E. Friedman Ching-Chia Ting Rudi Micheletti Isabelle Plaisance Mohamed Nemir Damien Maison Jasmin Kernen Iole Pezzuto Dominic Villeneuve Frédéric Burdet Mark Ibberson Stephen L. Leib Nathan J. Palpant Nouria Hernandez Samir Ounzain Thierry Pedrazzini
author_facet	Michael Alexanian Daniel Maric Stephen P. Jenkinson Marco Mina Clayton E. Friedman Ching-Chia Ting Rudi Micheletti Isabelle Plaisance Mohamed Nemir Damien Maison Jasmin Kernen Iole Pezzuto Dominic Villeneuve Frédéric Burdet Mark Ibberson Stephen L. Leib Nathan J. Palpant Nouria Hernandez Samir Ounzain Thierry Pedrazzini
author_sort	Michael Alexanian
title	A transcribed enhancer dictates mesendoderm specification in pluripotency
title_short	A transcribed enhancer dictates mesendoderm specification in pluripotency
title_full	A transcribed enhancer dictates mesendoderm specification in pluripotency
title_fullStr	A transcribed enhancer dictates mesendoderm specification in pluripotency
title_full_unstemmed	A transcribed enhancer dictates mesendoderm specification in pluripotency
title_sort	transcribed enhancer dictates mesendoderm specification in pluripotency
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0401f32188554c209d1d26fb94e3d2e8
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A transcribed enhancer dictates mesendoderm specification in pluripotency

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